基质金属蛋白酶9在异位子宫内膜中的表达

目的通过研究基质金属白酶(MMPs)在异位及在位子宫内膜中的表达,探讨MMPs在子宫内膜异位症中起的作用。方法采用明胶酶谱法对异位有在位子宫内膜组织中基质金属蛋白酶9(MMP-9)进行测定,酶活性由凝胶图象分析系统进行分析。结果 异位及在位内膜组织均有MMP-9的表达,异位内膜显著高于在位内膜,并且随子宫内膜异位症严重程度的增强,其表达增高。结论 子宫内膜异位症病人异位内膜组织MMPs的表达增高,MMPs在异位组织的种植和侵袭过程中可能发挥重要作用。

Expression of metalloproteinase-9 in ectopic endometrium in women with endometriosis

Objective To study the expression of matrix metalloproteinase-9 (MMP-9) in ectopic and eutopic endometriumfrom women with endometriosis, thereby to determine the role of matrix metalloprotcinases in the pathogenesis ofendometrio-sis. Methods Both ectopic and eutopic endometrium tissue specimens were obtained from 30 women with endometriosis,and gelatinase activity in the specimens was detected by Zymography and quantitatCd by Gel Documentation Analysis System.Results MMP-9 was detected in both eutopic and ectopic endometrium, but the latter contained higher levels of MMP-9 thanthe former did, and as the endometriosis worsened. MMP-9 expression tended to increase further Conclusion Endometriotictissue possesses higher level of gelatinase activity than eutopic endometrium from patients with endometriosis does, andMMP-9 might be of importance for the implantation and invasive growth of endometriotic tissue that may lead to endometrio-sis.