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| 大鼠肝硬变门脉高压症模型建立方法改进 | |
| 引用本文： | 周丁华,应大君,肖凌云,朱楚洪,麻晓林. 大鼠肝硬变门脉高压症模型建立方法改进[J]. 中国普外基础与临床杂志, 2000, 7(1): 22-24 |
| 作者姓名： | 周丁华 应大君 肖凌云 朱楚洪 麻晓林 |
| 作者单位： | 1. 解放军二炮总医院普外科,北京,100088 2. 第三军医大学基础部,重庆 3. 第三军医大学附属大坪医院普外科,重庆,400042 |
| 基金项目： | 国家自然科学基金!资助号39770207 |
| 摘 要： | 目的 建立稳定的肝硬变门脉高压症模型。方法 对大鼠在左肾周围去血管化后皮下注射四氯化碳，然后观察肝脏组织形态学、门静脉系血管压力及分布、肝外门静脉系及侧支循环变化。结果 实验性肝硬变在形成过程中历经肝细胞变性坏死，纤维组织增生及上叶形成过程。实验第５周始，门静脉压力显著高于对照组；实验第１５周时，食管静脉管径显著大于对照组。结论大鼠左肾静脉周围去血管化后皮下注射四氯化碳所诱导的大鼠肝硬变门脉高压症 |
| 关 键 词： | 大鼠 门脉高压症 动物模型 改进 |
| 文章编号： | 1007-9424(2000)01-0022-03 |
| 修稿时间： | 1999-01-24 |
MODIFIED PROCEDURE FOR RAT MODEL OF HEPATOCIRRHOSIS WITH PORTAL HYPERTENSION IN RATS |
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| ZHOU Ding-huaYING Da-jun,XIAO Ling-yun,et al.. MODIFIED PROCEDURE FOR RAT MODEL OF HEPATOCIRRHOSIS WITH PORTAL HYPERTENSION IN RATS[J]. Chinese Journal of Bases and Clinics In General Surgery, 2000, 7(1): 22-24 | |
| Authors: | ZHOU Ding-huaYING Da-jun XIAO Ling-yun et al. |
| Affiliation: | ZHOU Ding-hua(Department of Hepatic-Biliary Surgery,The PLA 262 Hospital,Beijing 100088)YING Da-jun,XIAO Ling-yun,et al. |
| Abstract: | Objective To establish the reliable model of hepatocirrhosis with portal hypertension. Methods Carbon tetrachloride was subcutaneous injected after devascularization of the circumference of the left renal vein. The morphology of liver, the extrahepatic portal system and portcaval collateral circulation were observed. Results The liver of rats underwent degeneration and necrosis of hepatocytes, and the normal architecture of the liver lobules was replaced by pseudolobules, which consisted of regenerative hepatocytes and fibrous septa. After 5 weeks, the portal pressure was significantly higher than that of control ( P <0.05). The diameter of esophageal vein was significantly larger than that of control at 15th week ( P <0.05). Conclusion This technique is simple and reliable and can be applied for various experimental studies on portal hypertension. |
| Keywords: | Rat Portal hypertension Model |
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