Early rather than delayed administration of lisinopril protects the heart after myocardial infarction in rats |
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Authors: | LAM Zornoff BB Matsubara LS Matsubara SAR Paiva J Spadaro |
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Institution: | (1) Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, UNESP, CEP: 18618-000, Botucatu – SP – Brazil, BR |
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Abstract: | Background:ACE inhibitors have shown beneficial results in several studies after myocardial infarction (MI). However, this studies have
shown conflicting results about the ideal starting time of the ACE inhibitors administration after MI and the importance of
infarct size.
Objectives: This study was designed to assess the long-term effects of lisinopril on mortality, cardiac function, and ventricular fibrosis
after MI, in rats.
Methods: Lisinopril (20 mg/kg/day) was given on day 1 or 21 days after coronary occlusion in small or large infarctions.
Results: The mortality rate was reduced by 39% in early treatment and 30% in delayed treatment in comparison to the untreated rats.
Early treatment reduced cardiac dysfunction in small MIs; however, delayed treatment did not. No statistical difference was
observed among the groups for large MIs. No statistical difference was observed among the groups with large or small MIs on
myocardial hydroxyproline concentration.
Conclusions: Both early and delayed treatments with lisinopril increased survival. Treatment exerts no marked effects on fibrosis; early
treatment has exerted beneficial influences on cardiac function whereas delayed treatment had no consistent effects. The protective
effect of lisinopril is detectable only in small (< 40% of LV) MIs.
Received: 6 May 1999, Returned for 1. revision: 28 May 1999, 1. Revision received: 20 July 1999, Returned for 2. revision:
26 August 1999, 2. Revision received: 28 September 1999, Accepted: 29 September 1999 |
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Keywords: | Myocardial infarction – ventricular remodeling – angiotensin – converting enzyme inhibitor – lisinopril – rat |
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