| 二甲苯对雄性小鼠生殖细胞遗传损伤作用的研究 |
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| 引用本文： | 王小芬 张树来. 二甲苯对雄性小鼠生殖细胞遗传损伤作用的研究[J]. 卫生研究, 1993, 22(6): 324-327 |
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| 作者姓名： | 王小芬 张树来 |
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| 作者单位： | 山东省劳动卫生职业病防治研究所 济南250001 |
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| 摘 要： | 雄性小鼠经口给467mg/kg和1400mg/kg剂量的二甲苯,致小鼠初级精母细胞染色体畸变率显著增高,性染色体及常染色体早熟分离发生率显著高于对照组;腹腔注射56mg/kg和280mg/kg剂量二甲苯,小鼠精原细胞SCE频率增高。两项试验结果一致,表明二甲苯对雄性小鼠生殖细胞有致突变作用。
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| 关 键 词： | 二甲苯 雄性小鼠 生殖细胞染色体畸变 姐妹染色单体交换 |
Studies of xylene on germ cells damage of male mice |
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| Wang Xiaofen,Zhang Shulai,Liu Yongxia,et al.. Studies of xylene on germ cells damage of male mice[J]. Journal of hygiene research, 1993, 22(6): 324-327 |
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| Authors: | Wang Xiaofen Zhang Shulai Liu Yongxia et al. |
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| Affiliation: | Shandong Institute of industrial Hygiene and Occupational Disease |
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| Abstract: | This study deals with the damage of xylene on germ cells of malemice,Xylene in doses of 457mg/kg and 1400mg/kg were administered byoral, and xylene in doses of 56mg/kg and 280mg/kg were administered in-traperitoneally to male, mice.The results showed: the frequencies of pri-mary spermatocyte chromosomal aberration,spermatogonia SCE in experi-mental groups were significently higher than that of the control group.The results of two experiments were identical.This study revealed thatxylene has toxic effects on germ cells and induced mutation on germcells of male mice. |
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| Keywords: | xylene male mice germ cell chromosomal aberration SCE |
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