Studies on herpes simplex virus type 1 glycoproteins using monoclonal antibodies |
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| Authors: | J Koga S Chatterjee R J Whitley |
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| Affiliation: | 1. Hacettepe University Faculty of Medicine, Department of Internal Medicine, Medical Intensive Care Unit, Ankara, Turkey;2. The University of Texas, MD Anderson Cancer Center, Houston, USA;3. Hacettepe University Faculty of Medicine, Department of Pediatrics, Division of Immunology, Ankara, Turkey;4. Hacettepe University Faculty of Medicine, Department of Basic Oncology, Ankara, Turkey;5. Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, Turkey |
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| Abstract: | Monoclonal antibodies against herpes simplex virus type 1 glycoproteins were isolated and utilized to study the synthesis and processing of glycoproteins B, C, and D (gB, gC, gD, respectively). Monoclonal antibodies against both gB and gD had higher virus-neutralizing activity when compared to that of gC. Differences among these glycoproteins were observed in their time of appearance in the virus-infected cells. The presence of gD was detected at a very early stage of infection when compared to gB and gC. The localization of these glycoproteins during their synthesis and processing was studied. |
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