原发性上颌骨霍奇金淋巴瘤一例并文献复习

 目的　提高对原发性骨霍奇金淋巴瘤的诊断和治疗的认识，加强对其病理组织学和影像学表现特点的认识。方法　报道1例原发性上颌骨霍奇金淋巴瘤的临床表现、实验室特征和治疗经过，并复习国内外相关文献。结果　患者以右上颌骨疼痛起病，X线显示上颌骨右侧可见大片溶骨性破坏，破损边缘不清晰，有部分骨硬化表现。手术摘除肿块，病理检查为霍奇金淋巴瘤淋巴细胞消减型，临床诊断为右上颌骨原发性霍奇金淋巴瘤（Ⅰ期）。给予ABVD方案治疗，无明显不良反应。结论　原发性骨霍奇金淋巴瘤是一种非常罕见的骨恶性淋巴瘤，容易误诊，目前确诊主要依靠病理及免疫组织化学。应尽早明确诊断，并加以鉴别诊断，现代化疗方案的预后较好。

Primary Hodgkin disease of the supermaxilla: a case report and review of the literatures

Objective To intensify the diagnosis and treatment of primary osseous Hodgkin disease (HD) and reinforce the impression of its features of pathology and imaging. Methods The clinical manifestation, laboratory examination, treatment and outcome of a patient with primary Hodgkin disease of the supermaxilla were first reported and the pertinent literatures were reviewed. Results Pain of the right supermaxilla was the first clinicM symptom. Plain X-rays showed mixed osteolytic and partially osteosclerotie lesions in the right supermaxiUa. The tumor was removed and the pathohistology was HD lymphocyte-depletion. The clinical diagnosis was primary HD of the supermaxilla (Stage Ⅰ ). The case was treated with ABVD regimen and no obviously adverse reaction appeared. Conclusion Primary osseous HD rarely presents as a malignant bone lymphoma and is easily misdiagnoed. Pathological and immunohistologic studies can be useful to confirm the diagnosis of primary osseous HD. Early diagnosis and the differentiation from other disease should be performed and the prognosis of the present-day chemotherapy regimen appears good.