毛细支气管炎患儿尿白三烯E4检测及其意义

目的通过检测毛细支气管炎(毛支)患儿尿白三烯E4(LTE4)水平及特应质对其的影响来探讨毛支患儿预后。方法对47例毛支患儿急性期恢复期及25例对照组进行尿LTE4测定,对急性期患儿同时检测嗜酸性粒细胞计数(EC)。结果毛支急性期尿LTE4水平(62.11±12.23)pmol/L较对照组(22.19±1.50)pmol/L、恢复期(34.86±5.75)pmol/L明显升高(P均<0.01),恢复期较对照组明显升高(P<0.01);与轻度毛支组(59.16±12.25)pmol/L比较,重度组患儿尿LTE4水平(98.04±8.04)pmol/L明显升高(P<0.01);特应质组(88.75±10.45)pmol/L毛支患儿尿LTE4水平较非特应质组(55.28±11.44)pmol/L明显升高(P<0.01);急性期毛支患儿尿LTE4水平与外周血EC计数无相关性(r=0.367,P>0.05)。结论毛支急性期尿LTE4产生增加,恢复期尿LTE4水平仍维持于高水平;重症毛支患儿尿LTE4水平明显升高,提示尿LTE4水平与病情严重程度有关;白三烯是影响特应质毛支患儿预后的重要的炎症介质;外周血EC不能很好的反映...

Test of urine leukotriene FA in infants with bronchiolitis and its clinical value

Objective To study the prognosis of infants with bronchiolitis by testing urine leukotriene E4 (LTE4) level and investigating atopy's influences. Methods Urine LTE4 was tested in 38 eases with mild bronchiolitis (47 in acute stage, 17 in convalescent stage), 9 severe bronchiolitis cases, 15 atopic cases, 25 control cases. Peripheral blood was used to determine eosinophils count (EC) in acute bronchiolitis cases. Results (1) The level of urine LTE4 is obviously higher in cases of acute group (62.11 ± 12.23 pmol/L) than that of control group (22.19±1.50 pmol/L) , and the convalescent group (34.86 ±5.75 pmol/L) (F = 132.42, P < 0.01) ;Urine LTE4 level of convalescent group is higher than that of the control group (P < 0.01). (2) Urine LTE4 level is significantly higher in severe group (98.04 ± 8.04 pmol/L) than that of mild group (59.16 ± 12.25 pmol/L) (t = 9.92, P < 0.01). (3) Urine LTE4 level of atopy positive (88.75 ± 10.45 pmol/L) infants with bronchiolitis is significantly higher than atopy negative infants (55.28 ± 11.44 pmol/L)(t = 8.63, P < 0.01). (4) There is no significant correlation between the levels of urine LTE4 and EC for acute bronchiolitis. Condusions The level of urine LTE4 in acute bronehiolitis patients increases and remains high in convalescent stage;Higher urine LTE4 level in severe bronchiolitis cases indicates that urine LTE4 level is related to the severity of the disease;cysteinylleukotrenes is an important mediator of inflammation that may influence the prognosis of atopy positive infants with bronchiolitis;EC is not a good index to present the airway inflammation of infants with bronehiolitis.