果糖二磷酸钠辅助治疗冠心病

目的：观察果糖二磷酸钠（ＦＤＰ，１，６－二磷酸果糖）治疗冠心病的疗效。方法：５４例住院确诊冠心病病人（男性３９例，女性１５例；年龄６６±ｓ１０ａ）在常规药物治疗的同时每日加用ＦＤＰ５～１０ｇ，连续用药４ｗｋ，为ＦＤＰ组。另有相似６６例（男性４４例，女性２２例；年龄６７±１１ａ）在常规药物治疗同时加用葡萄糖－胰岛素－氯化钾（ＧＩＫ）注射液５００ｍＬ，静脉滴注，ｑｄ，连续用药４ｗｋ，为ＧＩＫ组，进行比较。结果：ＦＤＰ组临床总有效率８５％优于ＧＩＫ组５９％（Ｐ＜０．０５）。ＦＤＰ组治疗后ＳＶ，ＣＯ，ＬＶＥＦ，ＦＳ有明显升高（Ｐ＜０．０１或Ｐ＜０．０５），而ＧＩＫ组无此效应；ＦＤＰ组无毒副作用。结论：ＦＤＰ为治疗冠心病的安全、有效的辅助药物。

Fructose 1,6-diphosphate in supportive treatment of coronary disease

AIM: To observe the efficacy of fructose-1,6-diphosphate(FDP) in supportive treatment of coronary disease. METHODS: Fifty-four patients (M 39, F 15, age 66±s 10 a) with coronary diseases were given FDP 5-10 g, iv, gtt, qd, for 4 wk in addition to conventional therapy. The other 66 patients (M 44, F 22; age 67±11 a) were given GIK (glucose+insulin+KCl) injection 500 mL, iv, gtt, qd, for 4 wk in addition to conventional therapy. RESULTS: The clinical total effective response was 85% in the former group and 59% in the latter group (P<0.05). Definite hemodynamic (heart function) and clinical improvement were found in FDP group, with SV, CO, LVEF, FS increased in echocardiography (P<0.01 or P<0.05). CONCLUSION: FDP is a valuable and safe therapy in supportive treatment of coronary disease.