| 细胞膜渗透系数的研究 |
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| 引用本文： | 张凤宝,陈涛,张国亮,王绍亭,姜埃利,刘建勇,马腾骧,谭中. 细胞膜渗透系数的研究 [J]. 中国生物医学工程学报, 1995, 0(1) |
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| 作者姓名： | 张凤宝 陈涛 张国亮 王绍亭 姜埃利 刘建勇 马腾骧 谭中 |
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| 作者单位： | 天津大学生物医学工程研究所，天津医学院第二附属医院，天津泌尿外科研究所 |
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| 基金项目： | 天津市21世纪青年基金和国家教委优青年教师基金 |
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| 摘 要： | 提出了一个全血传质的两相模型和新的透析器清除率表达式，通过测定不同时刻血浆和细胞内溶质浓度，获得了尿素、肌酐和尿酸的细胞膜渗透系数，研究结果对医生准确地评价透析医疗效果和小型、高效透析器的开发具有重要意义。
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| 关 键 词： | 溶质清除率；两相模型；细胞膜渗透系数 |
INVESTIGATION ON RED BLOOD CELL PERMEABILITY |
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| Zhang Feng-bao,Chen Tao,Zhang Guo-liang and Wang Shao-ting. INVESTIGATION ON RED BLOOD CELL PERMEABILITY[J]. Chinese Journal of Biomedical Engineering, 1995, 0(1) |
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| Authors: | Zhang Feng-bao Chen Tao Zhang Guo-liang Wang Shao-ting |
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| Abstract: | A two-phase mass transfer model for whole blood and a new express-ion of hemodialyzer clearence based on the model were prescnted. Red bl-ood cell (RBC)membrane permeability for urea, creatinine and uric acidwas obtained by measuring the solute distribution between plasma and RBCin vitro. In contrast to urea to be diffused almost instantly through RBCmembrane, creatinine and uric acid were proven to traverse very slowly.The results could be used in accurate computation of hemodialysis therap-eutic effect and in developing small-sized high-efficiency hemodialyzer. |
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| Keywords: | Solute clearance Two-phase model RBC membrane permeabilily |
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