宫内TORCH感染对新生儿行为神经发育影响的研究

目的 研究宫内TORCH感染对新生儿神经行为发育的影响,为进一步干预提供依据。 方法 选择胎龄37~42周,脐血或外周血检查TORCH系列抗体一项或多项IgM(+),母亲在产前筛查或产时监测TORCH系列抗体一项或多项同种病原体IgM(+)的新生儿作为感染组,同期检查母亲及新生儿脐血或外周血TORCH感染均为阴性的100例新生儿为对照组,两组新生儿均在出生后48~72 h、12~14 d、26~28 d测查NBNA评分。 结果 新生儿风疹病毒、巨细胞病毒、疱疹病毒、弓形虫感染率统计学比较差异有统计学意义(P<0.05),其中巨细胞病毒感染率最高为1.48%,弓形虫感染率最低为0.12%;各时间段风疹病毒和巨细胞病毒感染组新生儿NBNA评分均低于对照组(P<0.05),弓形虫和疱疹病毒感染组新生儿NBNA评分与对照组差异无统计学意义(P>0.05),各感染组间NBNA评分差异无统计学意义(P>0.05)。同一感染组,新生儿NBNA评分在三个时间段比较差异均有统计学意义(P<0.05)。 结论 宫内TORCH 感染会影响新生儿行为神经的发育。

Impact of TORCH intrauterine infection on neonatal behavioral neurological development.

Objective To explore the impact of TORCH intrauterine infection on neonatal behavioral and neurological development. Methods Choosing gestational age 37~42 weeks,umbilical cord blood or peripheral blood check TORCH series antibody one or more IgM(+),the mother in the prenatal screening or intrapartum monitoring TORCH series antibody one or more same pathogen IgM(+) of newborn as the infection team,while mother and neonatal umbilical cord blood and peripheral blood TORCH infection were checked all negative of 100 cases of neonatal as control group,two groups of newborn babies born in 48~72 hours,12~14 days,26~28 days were examined of NBNA score. Results Neonatal rubella virus,cytomegalovirus,herpes virus,toxoplasma infection rate had statistics significant differences (P<0.05),including cytomegalovirus infection rate was up to 1.48%,the lowest toxoplasma infection rate was 0.12%;Each time rubella virus and cytomegalovirus infection group of neonatal NBNA scores were lower than those of the control group (P<0.05),toxoplasma and herpes virus infection group of neonatal NBNA score and control group had no significant difference (P>0.05),NBNA score had no significant difference among the infection groups(P>0.05).The same infection group,neonatal NBNA scores in three periods had the significant differences (P<0.05). Conclusion TORCH intrauterine infection will affect the development of neonatal behavioral neurological development.