1%盐酸布替萘芬乳膏治疗体股癣、足癣疗效观察

目的：评价1％盐酸布替萘芬乳膏治疗体股癣、足癣的临床疗效和安全性。方法：采用多中心、随机、双盲、平行对照的方法．试验组外用1％盐酸布替萘芬乳膏，对照组外用1％联苯苄唑乳膏。结果：体股癣患者停药时试验组与对照组痊愈率分别为32．76％和38．98％。有效率分别为93．10％和94．92％；停药2周时，试验组与对照组痊愈率分别为62．07％和64．41％，有效率分别为93．10％和96．61％。足癣患者停药时．试验组与对照组痊愈率分别为29．31％和30．00％．有效率分别为89．66％和85．00％；停药2周时，试验组与对照组痊愈率分别为48．28％和43．33％．有效率分别为91．38％和86．67％。局部不良反应发生率，两试验组为5．13％；两对照组为4．17％。上述各项指标，两组比较差异无统计学意义。结论：1％盐酸布替萘芬乳膏治疗体股癣、足癣安全有效。

Clinical study of butenafine hydrochloride 1% cream in the treatment of tinea pedis,tinea corporis and tineacruris

Objective:To investigate the efficacy and safety of butenafine hydrochloride 1% cream in the treatment of tinea pedis,tinea cruris and tinea corporis.Methods:A randomized,double-blind,parallel-group trial was used.Results:At the end of study,for tinea cruris and tinea corporis patients,the overall cure rate,the response rates of the test group vs the control group were 32.76% vs 38.98%,93.10% vs 94.92%.Tinea pedis patients were 29.31% vs 30.00%,89.66% vs 85.00%.Two weeks follow-up,for tinea cruris and tinea corporis were 62.07% vs 64.41% and 93.10% vs 96.61%.Tinea pedis patients were 48.28% vs 43.33% and 91.38% vs 86.67%.The local adverse reaction rates of two test groups vs two control groups were 5.13% vs 4.17%.There were no statistically significant differences between two groups on above-mentioned data.Conclusion:Butenafine hydrochloride 1% cream is effective and well-tolerated in the treatment of tinea pedis,tinea cruris and tinea corporis.