66例非乙醇性脂肪肝临床分析

目的观察应用多烯磷脂酰胆碱(易善复)联合辛伐他汀治疗非乙醇性脂肪性肝炎患者的临床疗效。方法东莞市企石医院2007年6月至2009年3月66例应用多烯磷脂酰胆碱联合辛伐他汀治疗的非乙醇性脂肪性肝炎患者,比较治疗前后患者的血清生化包括丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(SB)、γ-谷氨酰转移酶(γ-GT)、三酰甘油(TG)、总胆固醇(TC)、影像资料。结果患者ALT、AST、γ-GT、TG、TC显著下降,治疗前后比较差异有显著性意义(P<0.05);影像学检查治疗前后比较有显著性差异(P<0.01)。结论多烯磷脂酰胆碱联合辛伐他汀治疗非乙醇性脂肪性肝炎可以使血脂降低或恢复正常,并能促进肝功能异常患者的肝酶指标恢复,疗效显著,值得推广。

The Clinical Analysis of 66 Cases Non-alcoholic Fatty Liver Disease

Objective To observe the clinical efficacy ofpolyene phosphatidylcholine（Essentiale）combined simvastatin treatment of non-alcoholic fatty liver disease in patients. Methods In Qishi hospital of Dongguan from June 2007 to March 2009 66 cases of application of polyene phosphatidylcholine combined simvastatin treatment in patients with non-alcoholic fatty liver disease compared before and after treatment in patients with serum biochemistry, including ALT, AST, SB, 3,-GT, TG, TC, image data. Results ALT, AST, γ-GT, TG, TC in patients before and after treatment difference was statistically significant（P〈0.05）; imaging studies before and after treatment There was a significant difference（P〈0.01）. Conclusion Polyunsaturated phosphatidylcholine combined simvastatin treatment of non-alcoholic fatty liver disease can make lipid lowering or return to normal, and can promote abnormal liver function in patients with liver enzymes target recovery effect is significant, worthy to be promotion.