异丙酚与依托咪酯全麻诱导中对血流动力学的影响比较

目的 观察异丙酚与依托咪酯全麻诱导过程中对血流动力学的影响。方法 40例ASAⅠ-Ⅱ级全麻手术病人，随机分为异丙酚组（P组，n=20)麻醉诱导P组异丙酚1．5－2mg/kg、E组依托咪酯0．3mg/kg，加用安定0．2mg/kg，芬太尼2μg/kg、维库溴铵0．04－0．06mg/kg和琥珀胆碱1．5mg/kg。分别记录诱导前后两组的SBP、DBP和HR的变化。结果 诱导后P组SBP、DBP和HR均明显下降（P＜0．05），而E组则轻度下降或下降不明显，血流动力学与诱导前相比无明显变化（P＞0．05）。结论 异丙酚对血流动力学的影响较为严重，明显大于依托咪酯。

A Comparison of Effects of Propofol or Etomidate on Hemodynamics durigng Induction of General Anesthesia

Objective To investigate the effects of propofol or etomidate on hemodynamics druing induction of general anesthesia. Method Forty general anesthesia patients (ASA Ⅰ ～ Ⅱ ) were rendomly divided into group P( propofol, n = 20) and group E(etomidate, n = 20). Induction of anesthesia with propofol 1.5 ～ 2mg/kg in group P and with etomidate 0.3mg/kg in group E. Diazepamum 0.2ng/kg, Fentanyl 2μg/kg, Vecuronium 0.04 ～ 0.06 mg/kg and succinycholine 1.5mg/kg were given in two groups. The changes is SBP、DBP and HR were recorded before and after induction. Results After induction, the SBP、 DBP and HR were significantly decreased in group P(P ＜ 0.05), and less significantly decreased in group E, no signifieanty difference on hemodynamics before and after induction(P ＞ 0.05). Conclusion Effects of propofol on hemodynamics are obviously more potent than etomidate.