| 人肺癌细胞体外对抗癌药物敏感性的初探 |
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| 引用本文： | 唐东平,祝家兴,王威廉,王冰. 人肺癌细胞体外对抗癌药物敏感性的初探[J]. 中华肿瘤防治杂志, 1998, 0(2) |
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| 作者姓名： | 唐东平 祝家兴 王威廉 王冰 |
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| 作者单位： | 广西省肿瘤防治研究所 |
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| 摘 要： | 目的探讨人肺癌细胞体外对１０种抗癌药的敏感性及方法的可靠性。方法收集人肺癌手术切除的标本２０例，用一简单、快速，有一定特异性优点的ＭＴＴ（３－（４，５）－双甲基－２－唑噻－（２，５）－二苯基溴化四氮唑蓝）法作威猛、足叶乙甙、阿霉素、长春新碱、长春地辛、卡铂、平阳霉素、氟脲嘧啶、环磷酰胺和异环磷酰胺抗癌敏感药物试验。结果患者不同个体之间药物敏感性不同（Ｐ＜０．０１）：１０种药物平均抑制率以威猛类药物最高（Ｐ＜０．０１），依次为阿霉素、卡铂、足叶乙甙、长春地辛等。敏感药物顺序与临床治疗结果大致相符。结论用ＭＴＴ法可作肿瘤治疗个案化较为可靠的检测方法。
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| 关 键 词： | 抗肿瘤药，药敏试验，肺癌，MTT |
Effects of anti-cancer drugs on the cells of lung cancer in vitro |
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| Tang Dongping,Zhu Jiaxing,Wang Weilian et al. Effects of anti-cancer drugs on the cells of lung cancer in vitro[J]. Chinese Journal of Cancer Prevention and Treatment, 1998, 0(2) |
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| Authors: | Tang Dongping Zhu Jiaxing Wang Weilian et al |
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| Abstract: | We tested the effects of 10 kinds of anti-cancer drugs including VM-26 , VP15 , ADM ,VCR , VDS ,DDP ,BLM , 5FU , CTX and IFO on 20 cases of fresh lung cancer tissues by MTT method. The results showed that there were different effects on different cases of lung cancer. The most effcetive drug was VM- 26 ( P<0.01 ) . The effective order of these drugs corresponded with clinical treatment results. This method is suitable for choosing individual effective anti-cancer drugs in clinical practice. |
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| Keywords: | Anti-cancer drugs Drugs sensitivity test Lung cancer MTT |
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