联合检测尿转铁蛋白、α1-微球蛋白和血Cystatin C对糖尿病肾病早期诊断价值

目的：探讨联合检测尿转铁蛋白（TRF）、α1-微球蛋白（α1-MG）和血半胱氨酸蛋白酶抑制剂C（Cystatin C）对糖尿病肾病（DN）早期诊断的临床意义。方法：64例2型糖尿病患者根据尿白蛋白排泄率（UAER）分为3组,A组为正常白蛋白尿组（UAER≤20μg/min）22例,B组为微量白蛋白尿组（UAER 20～200μg/min）19例;C组为大量白蛋白尿组（UAER≥200μg/min）23例。收集并测定各组患者24 h尿微量白蛋白、TRF、α1-MG,同时检测血清肌酐及Cystatin C,比较各组患者指标的变化。结果：与A组相比,B组和C组TRF、α1-MG和血Cystatin C均显著增高,联合检测阳性率明显高于单项检测。结论：联合检测TRF、α1-MG和血Cystatin C可以反应DN的早期损害,有利于早期诊断。

Value of Combined Measurement of Urinary TRF, α1 - MG and Serum Cystatin C in Diagnosing Early Phase of Diabetic Nephropathy

Objective：To explore vα1ue of combined measurement of urinary transferrin （TRF）, α1 - MG and serum cystatin C in diagnosing the early phase of diabetic nephropathy （DN）. Methods：Sixty- four DN patients were divided into three groups according to their 24 h urinary α1bumin excretion rate （UAER） ：group 1 （normα1 α1buminuria） ,group 2 （microα1buminuria） ,group 3 （macroα1buminuria）. Urinary micro α1bumins, TRF, α1 - MG, serum creatinine （Scr） and serum cystatin C were measured, and these indexes among three groups were compared. Results：The levds of urinary TRF, α1 - MG and serum Cystatin C in group 2 and group 3 were significantly higher than that in group 1. Co - detection of urinary TRF, 1 - MG and serum Cystatin C may have significantly higher positive rate than single one. Conclusion：Co - detection of urinary TRF, α1 - MG and serum cystatin C may indicate early renal damage in DN, and it is vα1uabe in diagnosing DN in the early phase.