脑组织血管动态调节的无损伤测量研究

近红外光谱信号分析 (NIRS)近年来发展迅速并获得临床应用 ,人们一直试图用此方法得到精确的组织血液成分的信息 ,而没有挖掘其中蕴涵的血管动态调节的丰富信息。本文描述了一种新的近红外光谱信号分析方法 (NIRS) ,能区分出动脉血和静脉血的相对变化 ,实现脑组织血管动态调节的无损伤测量。通过设计一些可用已知生理学理论解析的方法诱发组织血管的调节作用 ,对比观察电磁血流量计和NIRS测量结果 ,并进行了人体实测研究。目的在于使由此而得到的血管调节信息易于判断与确信 ,从而有利于运用这种连续动态的光电检测法去观察更深层的生理与心理的未知现象。

NONINVASIVE ASSESSMENT OF THE DYNAMIC CEREBROVASCULAR REGULATION

Near infrared spectroscopy (NIRS) has been developed rapidly, some achievements have been applied to clinic. Up to now, all reports focused on quantifying the tissue blood oxygenation precisely, whereas overlooked the important information on vascular regulation hiding in signals of NIRS. This report presents a new technique of NIRS, which is able to detail the relative variation of vascular volume in artery and vein, and easy to access the dynamic cerebrovascular regulation non-invasively. The dynamic processes of cerebrovascular regulation in dogs were induced by noradrenaline or Tap Ning ginkgo leaves tablet and depicted both by electromagnetic flowmeter and NIRS. Furthermore, human cerebrovascular regulations stimulated by controlled thorax movements were observed. The objectives of the tests are to determine and validate the results of vascular regulation achieved by NIRS, and to promote the applications of this new technique to exploit more sophisticated and profound phenomena in physiology or psychology.