良性前列腺增生症与前列腺癌患者及健康者头发中5种微量元素的测定

用原子吸收光谱法测定良性前列腺增生 (BPH)和前列腺癌 (PCa)患者及健康者头发中铜、锌、铁、锰和镉5种元素的含量。结果表明 :PCa患者发锌含量较健康者及BPH显著减少 (P <0 .0 1) ,而其他 4种微量元素在三组间差异无显著性 (P >0 .0 5 )。发锌含量的显著降低 ,可能为早期前列腺癌的诊断提供重要线索

Investigation of trace elements in hair of patients with prostate carcinoma, benign prostatic hypertrophy, and normal controls

Five trace metals (Cd, Cu, Fe, Mn, and Zn)in the hair of healthy subjects(n=10) and patients with benign prostatic hypertrophy (n=17) and prostatic cancer (n=18) were determined using atomic absorption spectrophotometry. The results were that zinc level in patients with prostatic carcinoma (79.1±37.3) μg·g -1 ] was significantly lower than that in patients with benign prostatic hypertrophy (129±26.7) μg·g -1 ] and normal controls (152±31.5) μg·g -1 ] (All P<0.01); Cd, Cu, Fe, and Mn levels in the hair showed no statistic difference among the three groups (P>0.05). It is suggested that the low zinc level in the hair might provide an important clue for dignosing prostatic carcinoma at the early stage.