| 心外膜脂肪组织及其在房颤心肌结构重构和电重构中的作用 |
| |
| 引用本文： | 饶晋,杨潜,王志农. 心外膜脂肪组织及其在房颤心肌结构重构和电重构中的作用[J]. 第二军医大学学报, 2023, 44(3) |
| |
| 作者姓名： | 饶晋 杨潜 王志农 |
| |
| 作者单位： | 海军军医大学（第二军医大学）长征医院心胸外科,海军军医大学（第二军医大学）长征医院心胸外科,海军军医大学（第二军医大学）长征医院心胸外科 |
| |
| 基金项目： | 上海市“领军人才”计划(2015044). Supported by the “Leading Talent” Project of Shanghai (2015044). |
| |
| 摘 要： | 心房纤颤（atrial fibrillation, AF）是临床上最常见的心律失常之一，也是心血管疾病发病率和死亡率增加的重要原因。心外膜脂肪（epicardial adipose tissue, EAT）是位于脏层心包和心肌之间的一种特殊脂肪组织，研究表明EAT参与AF的发生与维持，但是具体机制尚未得到完全阐释。EAT来源的脂肪干细胞（adipose-derived stromal cells, ADSCs）分泌的细胞外囊泡(extracellular vesicles, EVs) 近年来受到重视。该文主要从EAT特点、定量检测及其与心肌结构与电重构的关系，特别是EVs对AF发生的影响等方面进行综述，以期进一步认识AF的发病机制，为今后的治疗提供新的思路。
|
| 关 键 词： | 心外膜脂肪组织；心房纤颤；结构重构；电重构 |
| 收稿时间： | 2021-12-20 |
| 修稿时间： | 2022-03-24 |
Epicardial adipose tissue and its role in the cardiac structural and electrical remodeling of atrial fibrillation |
| |
| Rao Jin,Yang Qian and Wang Zhinong. Epicardial adipose tissue and its role in the cardiac structural and electrical remodeling of atrial fibrillation[J]. Former Academic Journal of Second Military Medical University, 2023, 44(3) |
| |
| Authors: | Rao Jin Yang Qian Wang Zhinong |
| |
| Affiliation: | Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University(Second Military Medical University),Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University(Second Military Medical University),Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University(Second Military Medical University) |
| |
| Abstract: | Atrial fibrillation (AF), being one of the most common arrhythmias clinically, accounts greatly for the morbidity and mortality of cardiovascular diseases. Epicardial adipose tissue (EAT), a special adipose tissue, is anatomically located between the visceral pericardium and myocardium. Studies have shown that EAT is involved in the occurrence and maintenance of AF, but the specific mechanisms have not been fully elaborated. biological functions, EAT-derived extracellular vehicles (EVs) gained much attention recently. This review mainly focused on the characteristics and imaging detections of EAT, especially the role of EVs in the development of AF, and its relationship with myocardial remodeling, which may provide new insights on the pathogenesis of AF and reference for the treatment of AF in the future. |
| |
| Keywords: | epicardial adipose tissue atrial fibrillation structural remodeling electrical remodeling |
|
| 点击此处可从《第二军医大学学报》浏览原始摘要信息 |
|
点击此处可从《第二军医大学学报》下载全文 |
|
