益生菌在急性胰腺炎治疗中应用的研究进展

急性胰腺炎（AP）是因胰腺中胰酶异常的激活而对胰腺自身以及周围器官产生消化而引起的,以胰腺局部炎症反应为主要特征,严重者可导致器官障碍的急腹症。在AP的进展过程中,微循环障碍会导致肠道的缺血缺氧进一步导致上皮的损伤,从而限制肠道菌群的平衡,影响基础的免疫系统。肠道屏障需要一个连续的细胞层以及基质连接。在AP发病过程中,这种肠道屏障的完整性破坏,引起肠道内菌群移位至其他器官以及有益菌的减少,对患者导致进一步伤害,从而导致全身炎症反应综合征（SIRS）、多器官功能障碍综合征（MODS）甚至死亡。近年来,国内外学者对于通过改善肠道内环境而减轻AP的发展日益关注,在AP患者治疗过程中,补充益生菌可以保护修复AP患者的肠道黏膜屏障,同时减少患者发生菌群异位机会,改善肠道内微生态,对AP的治疗提供了新的思路。

Research progress in application of probiotics for treatment of acute pancreatitis

Acute pancreatitis (AP) is a condition in which the abnormal activation of pancreatic enzymes in the pancreas leads to digestion of the pancreas itself and surrounding organs, characterized mainly by local pancreatic inflammation, which can cause organ dysfunction and acute abdominal pain in severe cases. In the progression of AP, microcirculatory disturbances can lead to intestinal ischemia and hypoxia, which further causes epithelial damage, limiting the balance of gut flora and affecting the basic immune system. The gut barrier requires a continuous cellular layer and matrix connections. In the pathogenesis of AP, the integrity of this gut barrier is disrupted, which causes gut flora to shift to other organs, a decrease in beneficial bacteria, and further harm to patients, resulting in systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), and even death. In recent years, domestic and foreign scholars have paid increasing attention to the improvement of the gut environment to alleviate the development of AP. In the treatment of AP patients, supplementing probiotics can protect and repair the intestinal mucosal barrier of AP patients, while reducing the chance of gut flora translocation and improving gut microecology, which provides new ideas for the treatment of AP.