Plaque progression: Where,why, and how fast? A review of what we have learned from the analysis of patient data from the PARADIGM registry |
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| Institution: | 1. University of British Columbia and Department of Radiology, St. Paul''s Hospital, Vancouver, Canada;2. Prince of Wales Clinical School, UNSW Sydney, Sydney, Australia;3. Department of Cardiovascular Sciences, University of Leicester and the Leicester NIHR Biomedical Research Centre, Leicester, United Kingdom;4. Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland;5. Department of Diagnostic Radiology, Tohoku University Hospital, Miyagi, Japan;6. Division of Cardiology, Department of Internal Medicine, Chosun University Hospital, Gwangju, Republic of Korea;7. Department of Radiology, New York-Presbyterian Hospital, Weill Cornell Medicine, New York, USA;8. Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea;9. Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, South Korea;10. Icahn School of Medicine at Mount Sinai, Mount Sinai Heart, Zena and Michael A. Wiener Cardiovascular Institute, and Marie-Josée and Henry R. Kravis Center for Cardiovascular Health, New York, NY, USA;11. Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands;1. Fiona Stanley Hospital, Harry Perkins Institute of Medical Research, University of Western Australia, Perth, Australia;2. Centre for Cardiovascular Innovation, St Paul''s Hospital, Vancouver, Canada;1. University of Chicago (NorthShore) Cardiology Fellowship, United States;2. Advanced Cardiac Imaging, NorthShore University Health System, United States;3. University of Chicago Pritzker School of Medicine, United States;1. Department of Cardiology, Boston Children''s Hospital, Boston, MA, USA;2. Department of Pediatrics, Harvard Medical School, Boston, MA, USA;1. William Harvey Research Institute, Queen Mary University of London, Mile End Rd, Bethnal Green, London E1 4NS, UK;2. Royal Brompton & Harefield NHS Foundation Trust, Sydney St, Chelsea, London SW3 6NP, UK;3. West Hertfordshire Hospitals, Watford General Hospital, Hertfordshire, WD18 0HB, UK;4. Imperial College Healthcare NHS Trust, St. Mary''s Hospital, London W2 1NY, UK;5. Changi General Hospital, 2 Simei Street 3, 529889, Singapore;6. School of Biomedical Engineering and Imaging Sciences, King''s College London, UK |
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| Abstract: | Ischemic heart disease is the most common cause of mortality worldwide. The pathophysiology of myocardial infarction relates to temporal changes of atherosclerotic plaque culminating in plaque rupture, erosion or hemorrhage and the subsequent thrombotic response. Coronary computed tomographic angiography (CCTA) provides the ability to visualize and quantify plaque, and plaque progression can be measured on a per-patient basis by comparing findings of serial CCTA. The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry was established with the objective of identifying patterns of plaque progression in a large population. The registry comprises over 2000 patients with multiple CCTA scans performed at least two years apart. Unlike previous CCTA registries, a semi-automated plaque quantification technique permitting detailed analysis of plaque progression was performed on all patients with interpretable studies. Since the registry was established, 19 peer-reviewed publications were identified, and all are reviewed and summarized in this article. |
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| Keywords: | Coronary computed tomography angiography coronary artery disease Atherosclerosis Myocardial infarction |
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