DNA甲基化修饰在胰腺癌中的研究进展

胰腺癌的发病机制、早期诊断及治疗一直是医学界关注的热点与重点。近年来多项研究表明表观遗传学对肿瘤的发生发展发挥着重要的作用，其中DNA甲基化最常见。胰腺癌的发生发展与其相关癌基因或抑癌基因由于DNA甲基化水平变化引起的异常激活或抑制有关。DNA甲基化可能在体细胞突变前发生，且贯穿肿瘤的全过程，因此在肿瘤的诊断、治疗和预防中被广泛研究。笔者对DNA甲基化的概念、作用方式、在胰腺癌发生发展中所起的作用以及胰腺癌诊断和治疗上的前景作一综述，以期对胰腺癌未来的研究提供一定的参考。

Research progress of DNA methylation modification in pancreatic cancer

The pathogenesis, early diagnosis, and treatment of pancreatic cancer have always been a hot and important topic of concern in the medical community. In recent years, a number of studies have shown that epigenetics plays an important role in the occurrence and development of tumors, with DNA methylation being the most common form. The development of pancreatic cancer is related to the abnormal activation or inhibition of its related oncogenes or tumor suppressor genes due to changes in DNA methylation levels. DNA methylation may occur before somatic cell mutations and runs through the entire process of tumor development, and therefore, it has been widely studied in the diagnosis, treatment, and prevention of tumors. In this article, the authors provide an overview of the concept and mode of action of DNA methylation, its role in the initiation and progression of pancreatic cancer, and its prospects in the diagnosis and treatment of pancreatic cancer, in order to provide a reference for future research on pancreatic cancer.