对乳腺癌相关淋巴水肿患者结局影响的调查

目的 了解术后乳腺癌患者乳腺癌相关淋巴水肿的发生状况,并分析淋巴水肿对乳腺癌患者结局状况的影响.方法 采用横断面调查方法,调查301例乳腺癌术后患者,通过臂周测评评估患者的淋巴水肿发生状况,选用欧洲癌症治疗研究组织所制定的生活质量核心问卷中文版和上肢功能评定量表评估患者的结局状况.结果 本组患者乳腺癌相关淋巴水肿的发生频率15.0％（45例）,淋巴水肿组患者的躯体功能得分为（83.85 ±11.76）分,角色功能得分为（85.93±16.65）分,无淋巴水肿组躯体功能得分为（90.91±10.85）分,角色功能得分为（92.48±15.48）分,淋巴水肿组在这两个维度得分均低于无淋巴水肿组,差异均具有统计学意义（P＜0.05）；淋巴水肿组患者上肢功能评定量表得分为（15.00±13.00）分,无淋巴水肿组得分为（9.00±11.00）分,淋巴水肿组得分高于无淋巴水肿组,差异均具有统计学意义（Z=-3.882,P＜0.05）.结论 乳腺癌相关淋巴水肿会降低患者生活质量,导致患者的上肢功能障碍,对患者的结局状况造成负面影响.

Research on the effect of breast cancer-related lymphedema on outcomes of breast cancer patients

Objective To investigate the frequency of the breast cancer related lymphedema and its effects on the health outcomes of breast cancer survivors.Methods It was a cross-sectional study and 301 female breast cancer survivors were enrolled in the study.Circumference measurement were chosen to diagnose the lymphedema.Quality of life Questionnare-Core30 designed by European Organization for Research and Treatment of Cancer and Disabilities of Arm,Shoulder and Hand Scale were administered to assess the quality of life and upper limb function which were calculated as the main outcome variables.Results The incidence of the breast cancer related lymphedema was 15.0％.The patients with breast cancer related lymphedema had lower mean values in physical functioning and role functioning and the differences were statistically significant （P ＜0.05）,respectively.Patients with breast cancer related lymphedema had higher DASH scores and the difference was statistically significant （P ＜ 0.05）.Conclusions Breast cancer related lymphedema can not only decrease breast cancer survivors quality of life but also impair their upper limb function.It implied that breast cancer related lymphedema is a question which needed to be paid more attention.