老年男性载脂蛋白apo A-I和apo B-100与心血管疾病关联的研究

对378名老年男性进行了apo A-I和apo B-100的流行病学调查。表明,健康老年男性apo A-I为148±30mg/dl,apo B-100 97.3±28mg/dl。冠心病患者apo B-100增高(P<0.01)。高血压患者apo A-I降低(P<0.05),apo B-100增高(P<0.01)。这提示apo的变化可能是高血压患者易罹患冠心病的原因。apo B-100与胆固醇正相关(r=0.22,P<0.05),apo A-I与纤维蛋白原呈负相关(r=-0.2,P<0.05)。因此高apo A-I与低apo B-100是冠心病的保护因素。

The Relationship of Apolipoprotein A-I and B-100 to Cardiovascular Diseases in Aging Males

Apolipoprotein(apo) A-I and apo B-100 were examined in 378 aging males for studing the relationship of apolipoprotein to cardiovascular diseases. The results,showed that apo A-I and apo B-100 were 148±30mg/dl, 97.3±28mg/dl in the healthy aged subjects. Patients with CHD had the higher level of apo B-100(P<0.01)than the controls,Apolipolritein A-I was decreased (P<0.05),but apo B-100 was increased(P<0. 01)in the patients with hypertension which indicated that the change of apolipoprotein conld be a factor for patients with hypertension and sensitive to CHD. There were a positive correlation between apo B-100 and apo A-I cholesterol contents(r=0. 22,P<0.05)as well as a negative correlation between apo A-I and fibrinogen(r=-0.2,P<0.05)contents. Our data suggested that a higher content of apo A-I and lower content of apo B-100 might serve as the protective factors for CHD.