| 抗精神病药所致体重增加的研究 |
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| 引用本文： | 陈纯姿. 抗精神病药所致体重增加的研究[J]. 中国民康医学, 2001, 13(4): 217-219 |
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| 作者姓名： | 陈纯姿 |
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| 作者单位： | 515063,广东省汕头大学精神卫生中心 |
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| 摘 要： | 目的比较典型(氯丙嗪与舒必利)与非典型抗精神病药(维思通与氯氮平)对体重的影响.方法对单服维思通、舒必利、氯氮平、氯丙嗪其中一种的精神分裂症患者,于用药前后测定体重的变化.结果服药8周后四种药物引起体重增加如下维思通组2.40kg,舒必利组2.73kg,氯氮平组3.71 kg,氯丙嗪组4.98 kg,其中维思通组与氯丙嗪组比较差异有极显著性(P＜0.01);舒必利组与氯丙嗪组比较差异有显著性(P＜0.05).各组男女体重变化差异无显著性,但男性平均体重的增加较女性高.结论典型与非典型抗精神病药均引起体重增加,其中对体重影响从小到大为维思通＜舒必利＜氯氮平＜氯丙嗪.对体重影响的不同也导致同患病率的不同.上述各药对男女体重影响无明显不同.
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| 关 键 词： | 维思通 舒必利 氯氮平 氯丙嗪 体重 |
| 修稿时间： | 2001-02-19 |
Antipsychotic agents and weight gain. |
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| CHEN Chunzi. Antipsychotic agents and weight gain.[J]. medical journal of chinese peoples health, 2001, 13(4): 217-219 |
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| Authors: | CHEN Chunzi |
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| Affiliation: | CHEN Chunzi.Mental Health Center in Shantou City Guangdong Province,515063,China |
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| Abstract: | Objectives:To study influence of conventional antipsychotics medicine and newer ones on weight gain.Methods:The weight had been measured before and after using risperidone,sulpiride,clozapine or chlorpromazine.Results:Mean weight gain after 8 weeks were as follow:risperidone 2 40 kg,sulpiride 2 73 kg,clozapine 3 71 kg,chlorpromazine 4 98 Kg.A statistical significance was observed on risperidone and chlorpromazine,sulpiride and chlorpromazine.The weight had no significant change between men and women in each group.Conclusion:Both conventional and newer antipsychotics were associated with weight gain.The order of these drugs inducing weight gain was as follow:risperidone
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| Keywords: | Risperidone Sulpiride Clozapine Chlorpromazine Weight. |
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