激光小梁成形术前后对原发性开角型青光眼患者昼夜眼压变化影响

目的 评价选择性激光小梁成形术(Selective laser Trabeculoplasty SLT)对原发性开角型青光眼(primary open-angle glaucoma,POAG)昼夜眼压的影响.方法 POAG患者40例76只眼.倍频Q-开关532nm Nd YAG激光,3ns单脉冲,光斑直径400μm,激光击射下方180°范围小梁组织,能量0.53～0.89mJ,点数60～100点.气动眼压计测量术前及术后12周昼夜眼压,两组数值比较采用配对t检验.结果 术前平均眼压(21.6±2.87)mmHg(1mmHg=0.133KPa),术后平均眼压(18.7±1.36)mmHg,两组比较P＜0.05(t=7.69);手术前后6am点术眼眼压降低最明显,为6.9 mmHg.术前眼压高峰出现在6am,波谷最低在10pm,昼夜眼压波动6.4 mmHg;术后眼压高峰移至12时,最低在22时,昼夜眼压波动3.2 mmHg.结论 SLT治疗原发性开角型青光眼安全、可靠,可有效降低POAG患者的平均眼内压,降低昼夜眼压波动.

Intraocular pressure alterations around selective laser trabeculoplasty in primary open-angle glaucoma patients

Objective To evaluate the influence on intraocular pressure of primary open-angle glaucoma patients after selective laser trabeculoplasty.Methods Forty cases(76 eyes)of POAG,multiple-frequency Q,532nm Nd YAG 3ns single pulse laser(power 0.53-0.89mJ,60-100 points,laser diameter 400μm)was performed to inferior 180°trabeculum tissues.The intraocular pressure pre-operation and 12 weeks post operation were detected,data was analyzed by T test.Results The average intraocular pressure WSS 21.6±2.87 mmHg(1mmHg=0.133KPa)pre-operative and 18.7±1.36mmHg post operative,there was statistically significantdifference(t=7.69,P＜0.05);IOP decreased most obviously(6.9mmHg)at 6am.The peak IOP pre-operative appeared at 6am and the lowest IOP appeared at 10pm,the change of IOP was 6.4 mmHg;the peak IOP post-operative appeared at 12am and the lowest IOP appeared at 10pm,the change of IOP Was 3.2 mmHg.Conclusions SLT is a safe operation to POAG,it can decrease the mean IOP and IOP wave motion day and night effectively in POAG patients.