Congenital Na+ diarrhea: a new type of secretory diarrhea |
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Authors: | C Holmberg J Perheentupa |
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Affiliation: | Department of Pediatrics, Children''s Hospital, Helsinki, Finland |
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Abstract: | We report a new type of congenital "secretory diarrhea" in a 9-year-old girl that led to contraction and severe metabolic acidosis in the first weeks of life. Her fecal Na+ concentration was high and the pH alkaline. All known causes of secretory diarrhea were excluded. Our findings indicate a defect in the handling of Na+ and H+ in the distal ileum and colon. Treatment with orally administered Na-K-citrate supplementation has normalized her fluid and electrolyte status and allowed normal growth and psychomotor development, but the diarrhea has persisted. |
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Keywords: | Reprint requests: Christer Holmberg M.D. Children's Hospital University of Helsinki SF-00290 Helsinki 29 Finland. |
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