| 手性修饰的硼氢化钠对前手性酮的不对称还原 |
| |
| 引用本文： | 陈继俊,徐明华,施欣忠,倪沛洲,施耀曾. 手性修饰的硼氢化钠对前手性酮的不对称还原[J]. 中国药科大学学报, 2000, 31(5): 7-9 |
| |
| 作者姓名： | 陈继俊 徐明华 施欣忠 倪沛洲 施耀曾 |
| |
| 作者单位： | [1]中国药科大学有机化学教研室,南京 [2]江苏农用化学有限公司,南京 |
| |
| 摘 要： | 研究了以Ｎ－苄基－（３Ｓ，４Ｓ）－３，４－二羟基四氢吡咯修饰的硼氢化钠对前手性酮的不对称还原反应，合成了五个光学活性醇，同时研究了添加路易斯酸对还原反应光学产率的影响。
|
| 关 键 词： | 手性修饰 不对称还原 硼氢化钠 合成 前手性酮 |
| 修稿时间： | 2000-06-02 |
Asymmetric Reduction of Prochiral Ketones Using Chirally Modified Sodium Borohydride |
| |
| CHEN Ji-Jun,XU Ming-Hu,SHI Xin-Zhong,NI Pei-Zhou,SHI Yao-Zeng. Asymmetric Reduction of Prochiral Ketones Using Chirally Modified Sodium Borohydride[J]. Journal of China Pharmaceutical University, 2000, 31(5): 7-9 |
| |
| Authors: | CHEN Ji-Jun XU Ming-Hu SHI Xin-Zhong NI Pei-Zhou SHI Yao-Zeng |
| |
| Affiliation: | CHEN Ji-Jun,XU Ming-Hua 1,SHI Xin-Zhong,NI Pei-Zhou,SHI Yao-Zeng 2 Department of Organic Chemistry,China Pharmaceutical University,Nanjing 210009, 1Jiangsu Agricultural Chemistry Limited Liability Company,Nanjing 210024, 2Department of Chemi |
| |
| Abstract: | Optical active alcohols were prepared by one-step reduction of prochiral ketones using sodium borohydride modified by %N%-benzyl-(%3S,4S%)-3,4-dihydroxy pyrrolidine.The effect of adding Lewis acids on reduction was also studied. |
| |
| Keywords: | Chirally modify Asymmetric reduction Sodium borohydride Synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国药科大学学报》浏览原始摘要信息 |
|
点击此处可从《中国药科大学学报》下载全文 |
|
