抗风湿药物的肝损害

目前风湿性疾病的诊断与治疗较过去有了迅速的发展，随着新药物的不断出现及应用，药物的肝毒性愈发受到广泛的重视。在所有抗风湿药物中糖皮质激素的肝毒性发生率相对较低。几乎绝大多数非甾体抗炎药物（NSAIDs）均可引起肝功能异常，如血清转氨酶轻度增高，但是有明显临床症状的肝损害非常少见，不同种类的NSAIDs引起肝损害确切的发生率尚不十分明确。改变病情抗风湿药多数存在一定肝毒性，因作用机制不同，副作用发生也各异，如环孢素肝毒性明显，而羟氯喹相对少见。对生物制剂肝毒性的报道目前不多，且生物制剂临床上往往与其他抗风湿药物同时应用，以致肝损伤的原因不易确定。

Antirheumatic drug-induced hepatotoxicity

In now days, the diagnosis and treatment of Rheumatic Disease have been rapidly developed. With new medicine emerging and utilized, drug＇s hepatotoxicity is getting more wide attention. In all the antirheumatic medication, the incidence of hepatotoxicity of glucocorticoid is relatively low. Almost all the NSAIDs can cause Hepatic function abnormal, such as serum transaminase increases slightly, however hepatic lesion with obvious clinical symptom is rare, the incidence of hepatotoxicity of different NSAIDs is not clear. Most of DMARDs have hepatotoxicity, as the mechanism varies, the side effect is different from each other, for example, the hepatotoxicity of Cielosporin is obvious, however that of hydroxychloroquine is rare. The hepatotoxicity of biological agent has not been much reported, because biological agent is almost being used with other antirheumatic medication, the reason of hepatotoxicity is not easily acquired.