| CD30在变应性鼻炎患者鼻黏膜组织中的表达 |
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| 引用本文： | 徐志鸿,杨成章,唐伟. CD30在变应性鼻炎患者鼻黏膜组织中的表达[J]. 临床耳鼻咽喉头颈外科杂志, 2004, 18(11): 643-644,i003 |
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| 作者姓名： | 徐志鸿 杨成章 唐伟 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院耳鼻咽喉科,武汉,430022;华中科技大学同济医学院附属协和医院耳鼻咽喉科,武汉,430022;华中科技大学同济医学院附属协和医院耳鼻咽喉科,武汉,430022 |
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| 摘 要： | 目的 :探讨CD30在变应性鼻炎患者鼻黏膜组织中的表达 ,分析其在变应性鼻炎发病中的作用。方法 :应用免疫组织化学SP法和苏木精 伊红染色对 31例变应性鼻炎患者的下鼻甲黏膜 (变应性鼻炎组 )和 2 6例肥厚性鼻炎患者的下鼻甲黏膜 (对照组 )标本中CD30的表达进行检测 ,并进行统计学分析。结果 :变应性鼻炎组CD30细胞数显著高于对照组 ,其差异有统计学意义 (P <0 .0 5 )。结论 :在变应性鼻炎的鼻黏膜组织中存在着Th2细胞主导的黏膜反应 ,通过研究CD30的表达水平可了解变应性鼻炎中Th2反应的状态。
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| 关 键 词： | 抗原 CD30 鼻炎 变应性 |
| 文章编号： | 1001-1781(2004)11-0643-02 |
| 修稿时间： | 2004-06-03 |
Expression of CD30 in nasal mucosa of patients with allergic rhinitis |
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| XU Zhihong YANG Chengzhang TANG Wei. Expression of CD30 in nasal mucosa of patients with allergic rhinitis[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2004, 18(11): 643-644,i003 |
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| Authors: | XU Zhihong YANG Chengzhang TANG Wei |
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| Affiliation: | Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. |
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| Abstract: | OBJECTIVE: To study the role of CD30 in the pathogenesis of allergic rhinitis. METHOD: The specimens of thirty-one patients with allergic rhinitis and twenty-six control subjects were studied by immunohistochemical method to detect CD30 cell. A mean numbers of positive cells per high field (10 x 40) were counted. All data were analyzed with t-test. RESULT: The number of CD30+ cells in the nasal mucosa of patients with allergic rhinitis was significantly more than that in the controls (P < 0.05). CONCLUSION: This study suggests a T-helper 2-dominated mucosal reaction in the allergic rhinitis compared to the nonallergic groups,and the expression level of CD30 can reflect the T-helper 2-dominated mucosal reaction. |
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| Keywords: | Antigens CD30 Allergic rhinitis |
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