| 阿克他利与甲氨蝶呤治疗类风湿关节炎的比较 |
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| 引用本文： | 杨艳萍,沈霖,谢晶,周丕祺,刘保平,高兰.阿克他利与甲氨蝶呤治疗类风湿关节炎的比较[J].中国新药与临床杂志,2001,20(3):177-181. |
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| 作者姓名： | 杨艳萍 沈霖 谢晶 周丕祺 刘保平 高兰 |
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| 作者单位： | 同济医科大学附属协和医院 骨科研究室, |
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| 摘 要： | 目的 :比较阿克他利和甲氨蝶呤对类风湿关节炎 (RA)的疗效和安全性。方法 :12 0例RA病人随机分为 2组 ,阿克他利组 80例 ,口服阿克他利10 0mg ,tid× 12wk。甲氨蝶呤组 4 0例 ,口服甲氨蝶呤 10mg ,qw× 12wk。结果 :阿克他利组总有效率为 73% ,甲氨蝶呤组为 78% (P >0 .0 5)。不良反应发生率分别为 9%和 18% ,差异有显著意义 (P <0 .0 5)。结论 :阿克他利治疗类风湿关节炎的疗效与甲氨蝶呤相似 ,但在安全性方面明显优于甲氨蝶呤。
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| 关 键 词： | 类风湿关节炎 阿克他利 甲氨蝶呤 |
| 文章编号： | 1007-7669(2001)03-0177-03 |
Actarit vs methotrexate in
treating rheumatoid arthritis |
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| YANG Yan-ping,SHEN Lin,XIE Jing,ZHOU Pi-Qi,IU Bao-Ping,GAO Lan.Actarit vs methotrexate in
treating rheumatoid arthritis[J].Chinese Journal of New Drugs and Clinical Remedies,2001,20(3):177-181. |
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| Authors: | YANG Yan-ping SHEN Lin XIE Jing ZHOU Pi-Qi IU Bao-Ping GAO Lan |
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| Abstract: | AIM: To campare the therapeutic effects and security between actarit (MS 932) and methotrexate(MTX) in the treatment of rheumatoid arthritis(RA). METHODS: One hundred and twenty patients with RA were randomly divided into two groups. Eighty patients of actarit group receved actarit, 100 mg, po , tid for 12 wk. The other forty patients received methotrexate 10 mg, po , qw for 12 wk as control. RESULTS: The total effective rates were 73 % for actarit and 78 % for MTX ( P > 0.05). The adverse reactions were 9 % and 18 %( P <0.05). CONCLUSION: Actarit is as same as methotrexate in the therapeutic effect, but actarit is better than MTX in security. |
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| Keywords: | rheumatoid arthritis actarit methotrexate [ |
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