TSGF与CEA、CA19-9联合检测在大肠癌诊断中的应用评价

目的评价联合检测恶性肿瘤特异生长因子(TSGF)、癌胚抗原(CEA)和CA19-9在诊断大肠癌中的应用价值。方法取健康体检者259例、大肠癌285例(直肠癌182例、结肠癌103例)、大肠良性疾病167例(增生性息肉79例、炎性息肉57例、管状腺瘤31例)血清,同时检测血清中TSGF(分光光度法)、CEA和CA19-9水平(化学发光法)。结果 TSGF、CEA和CA19-9诊断大肠癌的敏感率分别为87.4%、53.3%和51.2%,TSGF敏感率明显高于CEA和CA19-9(P<0.05),三者联合检测敏感性可提高至91.9%。结论 TSGF诊断大肠癌的敏感度高于CEA、CA19-9,但特异性低于CEA、CA19-9。三者联合检测可提高大肠癌诊断的特异性和灵敏度。

Evaluate diagnosis values of combined detection of TSGF, CEA and CA19-9 in large intestinal cancer

Objective To evaluate diagnosis values of combined detection of TSGF,CEA and CA19-9 in large intestinal cancer.Methods The sensitivity of TSGF,CEA and CA19-9 on diagnosis in large intestinal cancer were 87.4%,53.3% and 51.2% respectively.The sensitivity of TSGF on diagnosis in large intestinal cancer was more sensitive than that of CEA and CA19-9(P<0.05).The sensitivity arise to 91.9% by combined detection of TSGF,CEA and CA19-9.Results Collecting the serum samples from 259 health people,285 large intestinal cancer patients(182 rectum cancer patients,103 colon cancer patients) and 167 large intestine benign disease patients(79 hyperplastic polyp patients,57 inflammatory polyp patients,31 canalicular adenoma patients),The serum level of TSGF(using spectrophotometric method),CEA and CA19-9(using chemiluminescence method) were detected at the same time.Conclusion The sensitivity of TSGF on diagnosis in large intestinal cancer was more sensitive than that of CEA and CA19-9,but its specificity was lower.The combination detection of TSGF,CEA and CA19-9 can increase the sensitivity and specificity on diagnosis in large intestinal cancer.