TT病毒在人类肝病中的感染状况分析

目的了解各类肝病患者TT病毒（transfusion-transmitted virus，TTV）的感染率，分析TT病毒与已知肝炎病毒的交叉感染情况，探讨TT病毒与肝硬化、肝癌的关系以及是否是非甲～非庚型肝炎患者的主要致病因子。方法采用微板双探针核酸杂交酶免疫方法对TTV基因扩增产物进行定性检测。结果东营地区不同人群TT病毒阳性率分别为，甲肝患者37.50%（6/16），乙肝患者40.00%（18/45），丙肝患者44.44%（24/54），戊肝患者31.25%（10/32），不明原因转氨酶升高患者25.93%（7/27），肝硬化患者47.06%（24/51），肝癌患者31.91%（15/41）。结论东营地区TT病毒存在与已知病毒性肝炎的合并感染，并且血源性传播肝炎的TT病毒感染率明显高于健康志愿人群。是已知肝炎病毒的辅助因子，并可能是肝硬化潜在的致病因子。

The Detection of TTv and its Clinical Relation with Human Liver Disease

Objective To determine the prevalence of Transfusion-transmitted Virus(TTV)infection in several groups of patients with liver disease and to further determine the cross infection with the known hepatitis virus;Find out the relationship between TTV,hepatic cirrhosis and hepatic carcinoma,and whether TTV is the main pathogenic factor of non A-E hepatitis.Methods TTV DNA was determined by using the sandwich hybridization on microplate.Results TTV DNA was detected in 6(37.5%) patients with Hepatitis A,18(40%)patients with Hepatitis B,24(29%)patients with Hepatitis C,7(25.93%)patients with unknown transaminase higher,24(47.06%)patients with hepatic cirrhosis,15/41(31.91%)patients with hepatic carcinoma in Dongying region.Conclusion In Dongying region TTV can confected with known viral hepatitis,the prevalence of TTV DNA in blood transfusion hepatitis(HBV/HCV) is significantly higher than it in healthy volunteer.TTV is the cofactor to other known hepatitis viruses and the causative agent of hepatocirrhosis.