Radioimmunoscintigraphy in patients with breast adenocarcinoma using technetium-99m labelled monoclonal antibody 170H.82: Report of a phase II study |
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Authors: | S. A. McQuarrie G. D. MacLean G. R. Boniface K. Golberg A. J. B. McEwan |
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Affiliation: | (1) University of Alberta, Edmonton, Alberta, Canada;(2) Cross Cancer Institute, Edmonton, Alberta, Canada;(3) Biomira, Inc., Edmonton, Alberta, Canada;(4) Nuclear Medicine, Department of Oncologic Imaging, Cross Cancer Institute, 11560 University Avenue, T6G 1Z2 Edmonton, AB, Canada |
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Abstract: | Fifty-three women with clinical evidence of adenocarcinoma of the breast were studied with technetium-99m labelled monoclonal antibody (MAb) 170H.82 at protein doses of 1, 2 and 4 mg. An overall per lesion efficacy of 83.5% sensitivity and 97.7% positive predictive value was obtained. Efficacy appears higher in lesions restricted to the breast and local regional disease than systemic metastases. For the 2 mg dose the breast/local regional disease efficacy was 90% sensitivity and 90.2% positive predictive value. The biodistribution of this MAb was best represented by a two-compartment model with a distribution-phase half-life of 4.0±1.4 h, followed by an elimination-phase half-life of 39.6±6.6 h. In all six patients studied, the crticial organ was the kidney, with a mean radiation absorbed dose of 37±6.9 mGy/GBq. The accuracy of this imaging technique allows the development of diagnostic strategies for the routine use of the compound in patients with breast cancer. |
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Keywords: | Radioimmunoscintigraphy Monoclonal antibody Breast adenocarcinoma Radiation dosimetry Pharmacokinetics |
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