β-Adrenergic receptors in rat cerebellum after neonatal X-irradiation: Effect of prolonged imipramine and lithium treatment |
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| Authors: | M Türck H Yeh DJ Woodward JE Schultz |
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| Institution: | 1. Pharmazeutisches Institut der Universität Tübingen, Auf der Morgenstelle 8, 7400 Tübingen F.R.G.;1. University of Texas Health Science Center, Dallas, TX. U.S.A. |
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| Abstract: | The actions of prolonged treatment of rats within imipramine or lithium chloride on the β-adrenergic cAMP generating system of the cerebellum were compared in normal animals and in rats degranulated by neonatal X-irradiation. Whereas in normal animals imipramine treatment is without significant effect on the cerebellar cAMP system but lowers the β-adrenoceptor density significantly, in degranulated animals the cAMP system becomes subsensitive towards norepinephrine after prolonged imipramine treatment. These data support the hypothesis that in the cerebellum imipramine acts predominantly on β-adrenoceptors located particularly on Purkinje cells. Prolonged lithium treatment exhibited no significant effects on β-receptors nor the noradrenergic cAMP generating system of normal and degranulated cerebella. |
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| Keywords: | To whom correspondence should be addressed in Tübingen |
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