复方丹参方对正常家兔血浆血小板粘聚性及TXA2、PGI2的影响

采用半体内实验方法 ,观察了复方丹参方对正常家兔血浆血小板聚集性、粘附性及TXA2 、PGI2 的影响。结果表明 :正常家兔口服复方丹参方 1 2、2 4、4 8g kg及Aspirin 4 4mg kg均显示出明显的抗ADP诱导的血小板聚集作用 ;明显抑制血小板粘附性 ;Aspirin明显降低正常家兔血浆TXA2 水平 (P <0 0 5 ) ;复方丹参方 (4 8g kg)明显升高血浆PGI2 的水平 (P <0 0 1) ;As pirin及复方丹参方各剂量组对血浆TXA2 /PGI2 比值均无明显影响。提示复方丹参方抗正常家兔血小板粘聚作用与促进 6 Ke to PGF1α的释放密切相关。

Effects on Platelet Aggregation and Adhesion,TXA2 and PGI2 of Plasma of Fufangdanshenfang in Normal Rabbits

Using semi-in vivo experiment method,we studied the effect of Fufangdanshwenfang on platelet aggregation and adhesion,TXA-2 and PGI-2 in normal rabbits.The results demonstrated that:given orally,both aspirin(4^4mg/kg) and Fufangdanshwenfang as different dosages(1^2,2^4,4^8g/kg) could markedly counteract ADP inducing platelet aggregation and inhibit platelet adhesion in normal rabbits.Moreover,aspirin could decrease the content of TXA-2 in plasma,and Fufangdanshwenfang(4^8g/kg)could markedly raise the content of PGI-2 in plasma.Both aspirin(4^4mg/kg)and Fufangdanshwenfang of different dosages had little effect on the proportion of TXA-2 and PGI-2 in plasma.The results suggested that the inhibition effect on platelet aggregation and adhesion of Fufangdanshwenfang was closely related to its promotion effect on the release of PGI-2 in normal rabbits.