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Pyrimidinylpyrroloquinolones as highly potent and selective PDE5 inhibitors for treatment of erectile dysfunction |
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| Authors: | Sui Zhihua Guan Jihua Macielag Mark J Jiang Weiqin Zhang Suying Qiu Yuhong Kraft Patricia Bhattacharjee Sheela John T Matthew Haynes-Johnson Donna Clancy Joanna |
| Affiliation: | Johnson & Johnson Pharmaceutical Research & Development, Drug Discovery, 1000 Route 202, Raritan, NJ 08869, USA. |
| Abstract: | A series of N-pyrimidinylpyrroloquinolones were discovered as extremely potent and selective PDE5 inhibitors. Representative compounds demonstrated in vivo efficacy in dog erectile dysfunction models and are orally bioavailable. |
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