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Neural correlates of local contextual processing deficits in schizophrenic patients |
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| Authors: | Fogelson Noa Ribolsi Michele Fernandez-Del-Olmo Miguel Rubino Ivo Alex Romeo Domenico Koch Giacomo Peled Avi |
| Affiliation: | 1. Department of Psychology, University of A Coru?a, La Coru?a, Spain;2. Clinica Psichiatrica, Dipartimento di Neuroscienze, Università Tor Vergata, Rome, Italy;3. Department of Physical Education, University of A Coru?a, La Coru?a, Spain;4. Casa di Cura Neuropsichiatrica Colle Cesarano, Tivoli, Italy;5. Stroke Unit, Dipartimento di Neuroscienze, Università Tor Vergata, Rome, Italy;6. Laboratorio di Neurologia Clinica e Comportamentale, Fondazione Santa Lucia, Rome, Italy;7. Bruce and Ruth Rappaport Faculty of Medicine, Technion–Israel Institute of Technology, Haifa, Israel |
| Abstract: | Deficits in processing contextual information are one of the main features of cognitive dysfunction in schizophrenia, but the neurophysiologic substrate underlying this dysfunction is poorly understood. We used ERPs to investigate local contextual processing in schizophrenic patients. Local context was defined as the occurrence of a short predictive series of stimuli occurring before delivery of a target event. Response times of predicted targets were faster in controls compared to patients. Schizophrenia patients failed to generate the P3b latency shift between predicted and random targets that was observed in controls and demonstrated a prominent reduction of the peak of an early latency context dependent positivity. The current study provides evidence of contextual processing deficits in schizophrenia patients by demonstrating alteration in the behavioral and neural correlates of local contextual processing. |
| Keywords: | Context EEG P3b Schizophrenia Neural correlate |
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