金匮肾气丸联合克拉霉素治疗老年慢性前列腺炎的临床研究

目的探讨金匮肾气丸联合克拉霉素缓释片治疗老年慢性前列腺炎的临床疗效.方法选取2015年2月—2016年10月秦皇岛市第二医院收治的老年慢性前列腺炎患者134例,所有患者均采用随机数字表法分成对照组和治疗组,每组各67例。对照组口服克拉霉素缓释片,0.5 g/次,1次/d。治疗组在对照组基础上口服金匮肾气丸,9 g/次,2次/d。两组均连续治疗30 d。观察两组的临床疗效,比较两组的美国国立卫生院制定的慢性前列腺炎症状指数(NIH-CPSI)评分、白细胞(WBC)计数和前列腺液分泌型免疫球蛋白A(s Ig A)水平。结果治疗后,对照组和治疗组的总有效率分别为76.12%、91.04%,两组比较差异有统计学意义(P0.05)。治疗后,两组疼痛、尿路症状、生活质量和总评分均显著下降,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组WBC计数均显著减少,同组治疗前后比较差异有统计学意义(P0.05);且治疗组WBC计数明显低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组s Ig A水平均显著下降,同组治疗前后比较差异有统计学意义(P0.05);且治疗组s Ig A水平明显低于对照组,两组比较差异具有统计学意义(P0.05)。结论金匮肾气丸联合克拉霉素缓释片治疗老年慢性前列腺炎具有较好的临床疗效,可改善临床症状,提高患者的生活质量,降低前列腺液s Ig A水平,具有一定的临床推广应用价值。

Clinical study on Jinkui Shenqi Pills combined with clarithromycin in treatment of senile chronic prostatitis

Objective To investigate the clinical efficacy of Jinkui Shenqi Pills combined with Clarithromycin Sustained Release Tablets in treatment of senile chronic prostatitis. Methods Patients (134 cases) with senile chronic prostatitis in The Second Hospital of Qinhuangdao from February 2015 to October 2016 were randomly divided into control and treatment groups, and each group had 67 cases. Patients in the control group were po administered with Clarithromycin Sustained Release Tablets, 0.5 g/time, once daily. Patients in the treatment group were po administered with Jinkui Shenqi Pills on the basis of the control group, 9 g/time, twice daily. Patients in two groups were treated for 30 d. After treatment, the clinical efficacies were evaluated, and NIH-CPSI scores, WBC counts, and the sIgA levels in prostatic fluid in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.12% and 91.04%, respectively, and there was difference between two groups (P < 0.05). After treatment, the scores of pain, urinary symptoms, quality of life, and the total score in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the WBC counts in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the sIgA levels in prostatic fluid in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Jinkui Shenqi Pills combined with Clarithromycin Sustained Release Tablets has clinical curative effect in treatment of senile chronic prostatitis, can improve clinical symptoms, increase quality of life, and decrease the sIgA level in prostatic fluid, which has a certain clinical application value.