Low Level of O2 Inhibits Commitment of Cultured Mesenchymal Stromal Precursor Cells from the Adipose Tissue in Response to Osteogenic Stimuli |
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| Authors: | O. S. Grinakovskaya E. R. Andreeva L. B. Buravkova Yu. V. Rylova G. Yu. Kosovsky |
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| Affiliation: | (1) Stem Cells and Tissue Repair Group, Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore, 138673, Singapore;(2) School of Biomedical Sciences, University of Queensland, Brisbane, QLD, 4072, Australia;(3) Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 119074 Singapore, Singapore |
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| Abstract: | Mesenchymal stromal precursor cells from human lipoaspirate (lMSC) cultured at 5% O2 formed 50% less mineralized matrix in response to osteogenic induction than cells cultured under standard conditions (20% O2). After lMSC percultured at 5% O2 were transferred to normoxic conditions (20% O2), they produced the same amount of matrix as lMSC permanently cultured at 20% O2. Hence, hypoxia inhibited the commitment of lMSC under the effect of osteogenic stimuli, which can be important in reparative and regenerative medicine. |
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