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Ultra High-Resolution Anterior Segment Optical Coherence Tomography in the Diagnosis and Management of Ocular Surface Squamous Neoplasia |
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| Authors: | Benjamin J Thomas Anat Galor Afshan A Nanji Fouad El Sayyad Jianhua Wang Sander R Dubovy Madhura G Joag Carol L Karp |
| Institution: | 1. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA;2. Miami Veteran Affairs Medical Center, Miami, Florida, USA;3. Florida Lions Ocular Pathology Laboratory, Miami, Florida, USA;1. Department of Medicine and Ageing Sciences, Ophthalmology Clinic, University “G. D''Annunzio” of Chieti and Pescara, Chieti, Italy;2. Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham, United Kingdom;3. Ophthalmology Division and Rome Eye Bank, San Giovanni Hospital, Rome, Italy;4. Eye Clinic, Department of Neurological and Visual Science, University of Verona, Verona, Italy;1. Gavin Herbert Eye Institute, Irvine, CA, USA;2. Beckman Laser Institute and Medical Clinic, Irvine, CA, USA;3. Department of Biomedical Engineering, University of California, Irvine, CA, USA;4. Ocular Surface Center, Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA;1. Dalmia Ophthalmic Pathology Service, L.V. Prasad Eye Institute, Bhubaneswar, India;2. Ophthalmic Plastic Surgery, Orbit and Ocular Oncology, L.V. Prasad Eye Institute, Bhubaneswar, India;3. Ophthalmic Pathology Services, Professor Brien Holden Eye Research Centre, L.V. Prasad Eye Institute, Hyderabad, India;4. School of Medical Sciences, University of Hyderabad, Hyderabad, India |
| Abstract: | The development of optical coherence tomography (OCT) technology has helped to usher in a new era of in vivo diagnostic imaging of the eye. The utilization of OCT for imaging of the anterior segment and ocular surface has evolved from time-domain devices to spectral-domain devices with greater penetrance and resolution, providing novel images of anterior segment pathology to assist in diagnosis and management of disease. Ocular surface squamous neoplasia (OSSN) is one such pathology that has proven demonstrable by certain anterior segment OCT machines, specifically the newer devices capable of performing ultra high-resolution OCT (UHR-OCT). Distinctive features of OSSN on high resolution OCT allow for diagnosis and differentiation from other ocular surface pathologies. Subtle findings on these images help to characterize the OSSN lesions beyond what is apparent with the clinical examination, providing guidance for clinical management. The purpose of this review is to examine the published literature on the utilization of UHR-OCT for the diagnosis and management of OSSN, as well as to report novel uses of this technology and potential directions for its future development. |
| Keywords: | anterior segment OCT Fourier-domain OCT high-resolution OCT ocular surface squamous neoplasia optical coherence tomography (OCT) slit lamp OCT spectral domain OCT swept-source OCT time-domain OCT ultra high-resolution OCT 5-FU"} {"#name":"keyword" "$":{"id":"kwrd0065"} "$$":[{"#name":"text" "_":"5-Fluorouracil AS-OCT"} {"#name":"keyword" "$":{"id":"kwrd0075"} "$$":[{"#name":"text" "_":"Anterior segment optical coherence tomography FD-OCT"} {"#name":"keyword" "$":{"id":"kwrd0085"} "$$":[{"#name":"text" "_":"Fourier-domain optical coherence tomography HIV"} {"#name":"keyword" "$":{"id":"kwrd0095"} "$$":[{"#name":"text" "_":"Human immunodeficiency virus HR-OCT"} {"#name":"keyword" "$":{"id":"kwrd0105"} "$$":[{"#name":"text" "_":"High-resolution optical coherence tomography IFN"} {"#name":"keyword" "$":{"id":"kwrd0115"} "$$":[{"#name":"text" "_":"Interferon LASIK"} {"#name":"keyword" "$":{"id":"kwrd0125"} "$$":[{"#name":"text" "_":"Laser in situ keratomileusis LSCD"} {"#name":"keyword" "$":{"id":"kwrd0135"} "$$":[{"#name":"text" "_":"Limbal stem cell deficiency MMC"} {"#name":"keyword" "$":{"id":"kwrd0145"} "$$":[{"#name":"text" "_":"Mitomycin C OCT"} {"#name":"keyword" "$":{"id":"kwrd0155"} "$$":[{"#name":"text" "_":"Optical coherence tomography OSSN"} {"#name":"keyword" "$":{"id":"kwrd0165"} "$$":[{"#name":"text" "_":"Ocular surface squamous neoplasia SD-OCT"} {"#name":"keyword" "$":{"id":"kwrd0175"} "$$":[{"#name":"text" "_":"Spectral domain optical coherence tomography SLE"} {"#name":"keyword" "$":{"id":"kwrd0185"} "$$":[{"#name":"text" "_":"Slit lamp examination SL-OCT"} {"#name":"keyword" "$":{"id":"kwrd0195"} "$$":[{"#name":"text" "_":"Slit lamp optical coherence tomography SS-OCT"} {"#name":"keyword" "$":{"id":"kwrd0205"} "$$":[{"#name":"text" "_":"Swept-source optical coherence tomography TD-OCT"} {"#name":"keyword" "$":{"id":"kwrd0215"} "$$":[{"#name":"text" "_":"Time-domain optical coherence tomography UBM"} {"#name":"keyword" "$":{"id":"kwrd0225"} "$$":[{"#name":"text" "_":"Ultrasound biomicroscopy UHR-OCT"} {"#name":"keyword" "$":{"id":"kwrd0235"} "$$":[{"#name":"text" "_":"Ultra high-resolution optical coherence tomography |
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