Association between auditory P300, psychopathology,and memory function in drug-naïve schizophrenia |
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Authors: | Wei-Hung Chang Kao-Chin Chen Yen-Kuang Yang Po-See Chen Ru-Band Lu Tzung-Lieh Yeh Carol Sheei-Meei Wang I-Hui Lee |
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Institution: | 1. Department of Psychiatry, National Cheng Kung University Hospital, Douliou Branch, Yunlin, Taiwan;2. Addiction Research Center, National Cheng Kung University, Tainan, Taiwan;3. Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan;4. Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan;5. Department of Psychiatry, Tainan Hospital, Department of Health, Executive Yuan, Tainan, Taiwan |
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Abstract: | The aim of this study was to explore memory deficits and psychopathology and their relationships with P300 in drug-naïve patients with schizophrenia. The Positive and Negative Syndrome Scale (PANSS) and the Wechsler Memory Scale—Revised were administered. Auditory event-related potentials elicited by an oddball paradigm were obtained. After controlling for age, sex, the results showed a statistically significant negative correlation between the total PANSS score and P300 amplitude at the parietal position (r = ?0.66, p < 0.05). Moreover, visual memory was significantly positively correlated with P300 amplitude at the parietal position (r = 0.67, p < 0.05). After controlling for the duration of illness, the above correlations remained statistically significant. The correlation between P300 and the severity of psychopathology was reconfirmed in drug-naïve patients with schizophrenia. A possible contribution of memory decompensation in P300 among drug-naïve patients with schizophrenia may be considered, and the compensatory or Default Model Network might be a possible explanation of this association. |
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Keywords: | Default model network Drug-naïve schizophrenia P300 Psychopathology Visual memory |
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