血清8-OHdG、MnSOD水平与急性缺血性脑卒中患者rt-PA静脉溶栓后认知功能恢复的相关性分析

目的 探讨血清8-羟基脱氧鸟苷酸(8-OHdG)、锰超氧化物歧化酶(MnSOD)水平与急性缺血性脑卒中患者(AIS)经重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗后认知功能恢复情况的相关性.方法 选取2016年3月至2018年10月在本院进行rt-PA静脉溶栓治疗的112例AIS患者,根据患者溶栓治疗后7 d蒙特...

Analysis of correlation between the levels of serum 8-OHdG,MnSOD and the recovery of cognitive function in patients with acute ischemic stroke after intravenous thrombolysis with rt-PA

Objective To investigate the correlation between the levels of 8-hydroxydeoxyguanosine(8-OHdG),manganese superoxide dismutase(MnSOD)in serum and the recovery of cognitive function in patients with acute ischemic stroke(AIS)after intravenous thrombolysis with recombinant tissue plasminogen activator(rt-PA).Methods Totally 112 AIS patients who were treated with rt-PA intravenous thrombolysis in our hospital from March 2016 to October 2018 were selected,the patients were divided into two groups according to the score of the Montreal Cognitive Assessment Scale(MoCA)at 7 d after thrombolysis:those with MoCA score no less than 26 were in the good cognitive function recovery group(n=52),and those with MoCA score less than 26 were in the poor cognitive function recovery group(n=60).Differences in general data and laboratory indexes between the two groups were compared,and the factors that may affect the recovery of cognitive function in patients with AIS after rt-PA intravenous thrombolysis were analyzed.Results There were significant differences in atrial fibrillation history,NIHSS scores,hyperlipidemia history,diabetes history,time from onset to thrombolysis,8-OHdG,MnSOD,fasting blood glucose(FPG),total cholesterol(TC) and low-density lipoprotein cholesterol(LDL-C)between the good cognitive function recovery group and the poor cognitive function recovery group(P<0.05);Pearson correlation analysis showed that there was a negative correlation between serum 8-OHdG and MoCA score on the 7 th day after thrombolysis(P<0.05),and there was a positive correlation between MnSOD and MoCA score on the 7 th day after thrombolysis(P<0.05);multivariate Logistic regression analysis showed that 8-OHdG,FPG,TC,LDL-C and time from onset to thrombolysis were risk factors for cognitive function recovery after rt-PA intravenous thrombolysis in AIS patients(P<0.05),while MnSOD was the protective factor(P<0.05).Conclusion 8-OHdG,MnSOD,atrial fibrillation history,NIHSS scores,hyperlipidemia history,diabetes history,time from onset to thrombolysis,FPG,TC and LDL-C are closely related to the recovery of cognitive function in patients with AIS after rt-PA intravenous thrombolysis,which can provide a reference for predicting clinical prognosis.