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Association of NAT2, GST and CYP2E1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity
Authors:Neha Singla  Dheeraj Gupta  Niti Birbian  Jagtar Singh
Affiliation:1. Department of Biotechnology, Panjab University, Chandigarh 160014, India;2. Department of Pulmonary Medicine, PGIMER, Chandigarh 160012, India;1. Unit for Pharmacokinetics and Drug Metabolism, Department of Pharmacology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden;2. Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, South Africa;1. Radboud University Medical Centre, Department of Pulmonary diseases, Nijmegen and University Centre for Chronic Diseases Dekkerswald, Groesbeek, The Netherlands;2. Radboud University Medical Centre, Department of Pharmacy, Nijmegen, The Netherlands;3. University Medical Centre Groningen, Department of Hospital and Clinical Pharmacy, Groningen, The Netherlands;4. Radboud University Medical Centre, Department of Internal Medicine, Nijmegen, The Netherlands;5. Radboud University Medical Centre, Department for Epidemiology, Biostatistics and HTA, Nijmegen, The Netherlands;6. University Medical Centre Groningen, Tuberculosis Centre Beatrixoord, Haren, The Netherlands;7. University Medical Centre Groningen, Department of Internal Medicine, Groningen, The Netherlands;1. Universidade do Estado do Rio de Janeiro (UERJ), Departamento de Bioquímica, Rio de Janeiro, RJ, Brazil;2. Universidade do Estado do Rio de Janeiro (UERJ), Disciplina de Reumatologia, Rio de Janeiro, RJ, Brazil;1. Postgraduate Program of Clinical Pharmacy, Faculty of Pharmacy, Ahmad Dahlan University, Jl prof Dr Soepomo, Janturan 55164, Yogyakarta, Indonesia;2. National Institute for Health Research and Development, Jl. Percetakan Negara 29, Jakarta Pusat 10560, Jakarta, Indonesia;3. Faculty of Medicine, Universitas Gadjah Mada, Jl. Farmako Sekip 55281, Yogyakarta, Indonesia;1. Pharmacogenetics Research Laboratory, Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil;2. Human Genetic Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil;3. Technical Assistance of Clinical Research and Reference Services, Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil;4. Tuberculosis and Mycobacteria Clinical Research Laboratory, Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil;5. Genetics and Molecular Biology Department of Federal University of Rio de Janeiro State, Brazil;1. Riga Stradins University, Riga, Latvia;2. Latvian Biomedical Research and Study Center, Riga, Latvia;3. Riga East University Hospital, Centre of Tuberculosis and Lung Diseases, Riga, Latvia;4. University of Latvia, Riga, Latvia
Abstract:
Keywords:Tuberculosis  N-acetyltransferase 2 (NAT2)  Cytochrome P4502E1 (CYP2E1) and glutathione S-transferases (GSTs)  Anti-tuberculosis drug-induced hepatotoxicity (ATDH)
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