Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

Mitochondria,which play central roles in immunometabolic diseases,have their own genome.However,the functions of mitochondria-located noncoding RNAs are largely unknown due to the absence of a specific delivery system.By circular RNA(circRNA)expression profile analysis of liver fibroblasts from patients with nonalcoholic steatohepatitis(NASH),we observe that mitochondrial circRNAs account for a considerable fraction of downregulated circRNAs in NASH fibroblasts.