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Enhancement of in vitro activity of tuberculosis drugs by addition of thioridazine is not reflected by improved in vivo therapeutic efficacy
Authors:Gerjo J. de Knegt  Marian T. ten Kate  Dick van Soolingen  Rob Aarnoutse  Martin J. Boeree  Irma A.J.M. Bakker-Woudenberg  Jurriaan E.M. de Steenwinkel
Affiliation:1. Erasmus MC, University Medical Centre Rotterdam, Department of Medical Microbiology & Infectious Diseases, Rotterdam, The Netherlands;2. National Institute for Public Health and the Environment (RIVM), National Mycobacteria Reference Laboratory, Bilthoven, The Netherlands;3. Radboud University Medical Centre, Department of Pharmacy, Nijmegen, The Netherlands;4. Radboud University Nijmegen Medical Centre, University Centre for Chronic Diseases Dekkerswald, Nijmegen, The Netherlands;1. Grupo de Investigación en Inmunología y Enfermedades Infecciosas, Departamento de Patología, Facultad de Ciencias de la Salud, Universidad del Cauca, Calle 5a #4-70, Popayán, Colombia;2. Grupo de Inmunología Celular e Inmunogenética, Facultad de Medicina and Sede de Investigación Universitaria, Universidad de Antioquia, Carrera 53 #61-30 Lab 410, Medellín, Colombia;3. Centro Colombiano de Investigación en Tuberculosis (CCITB), Carrera 72 A No. 78 B 141, Medellín, Colombia;4. Unidad de Citometría de Flujo, Sede de Investigación Universitaria, Universidad de Antioquia, Carrera 53 #61-30 Lab 410, Medellín, Colombia;6. Departamento de Ciencias Fisiológicas, Facultad de Ciencias de la Salud, Universidad del Cauca, Calle 5a #4-70, Popayán, Colombia;1. Department of Pharmacology & Pharmacotherapy, University of Szeged, Szeged, Hungary;2. Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary;3. Servier, Budapest, Hungary;4. Gedeon Richter Plc., Pharmacology and Drug Safety Department, Budapest, Hungary;5. Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary;1. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;2. Task Applied Science, Bellville, Cape Town, South Africa;3. MRC Centre for Molecular and Cellular Biology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;4. Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa;5. Department of Statistics, Faculty of Natural Sciences, University of the Western Cape, Cape Town, South Africa;1. Unidad de Bioinformática y Biología Molecular, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru;2. Department of International Health, Bloomberg School of Public Health, The Johns Hopkins University, USA;3. Centro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Mexico;4. Laboratorio Universitario de Proteómica, Instituto de Biotecnología, Universidad Nacional Autónoma de Mexico, Mexico;1. State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, PR China;2. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, PR China;1. Department of Thoracic Medicine and Infectious Disease, Nordsjaelland Hospital, Hillerød, Denmark;2. International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark;3. Dept. of Infectious Disease Epidemiology, Statens Serum Institut, Copenhagen, Denmark
Abstract:
Keywords:Murine model  Tuberculosis  Thioridazine  Synergy  Time-kill kinetics
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