Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis in East Asians: a systematic review and meta-analysis |
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| Authors: | Suzan Chen Linlu Zhao Darren M Roffey Philippe Phan Eugene K Wai |
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| Institution: | 1. University of Ottawa Spine Program, The Ottawa Hospital, 1053 Carling Ave., Ottawa, Ontario, Canada, K1Y 4E9;2. Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St., New Haven, CT, USA, 06510;3. Clinical Epidemiology Program, Ottawa Hospital Research Institute, 725 Parkdale Ave., Ottawa, Ontario, Canada, K1Y 4E9;4. Division of Orthopaedic Surgery, Department of Surgery, University of Ottawa, 1053 Carling Ave., Ottawa, Ontario, Canada, K1Y 4E9;1. Shriners Hospitals for Children–Philadelphia, 3551 North Broad Street, Philadelphia, PA 19140, USA;2. University of South Florida, Tampa, FL, USA;3. Abteilung für Wirbelsäulenchirurgie, Eifelklinik St. Brigida, Kammerbruchstrasse 8, 52152 Simmeranth, Germany;4. Setting Scoliosis Straight Foundation, San Diego, CA, USA;5. New York University Hospital for Joint Diseases, New York, NY, USA;6. Rady Children''s Hospital and Health Center, San Diego, CA, USA;7. Alfred I. duPont Hospital for Children, Wilmington, DE, USA;8. Johns Hopkins University, Baltimore, MD, USA;9. University of Miami, Miami, FL, USA;1. Software School, Dalian University of Technology, Dalian 116620, China;2. Dalian Neusoft Institute of Information, China;1. Department of Medical Oncology and Hematology, Princess Margaret Cancer Center, Toronto, Canada;2. Department of Oncology and Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea;3. Medical Oncology Unit, Istituto Neurotraumatologico Italiano (INI), Grottaferrata, Rome, Italy;4. Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan;5. Department of Urology, Kitasato University School of Medicine, Kanagawa, Japan;6. Department of Molecular Carcinogenesis, Netherlands Cancer Institute, Amsterdam, Netherlands;7. Medical Oncology Department, Stanford University Medical Center, Stanford, CA;8. Genitourinary, CNS, and Sarcoma Tumor Unit, Vall d'' Hebron University Hospital, Vall d'' Hebron Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona, Spain;9. Office of Scientific Affairs and Research, King Hussein Cancer Centre, Amman, Jordan;10. Division of Hematology-Oncology, Department of Medicine, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Korea;11. Department of Urology, Soonchunhyang University College of Medicine, Cheonan, Chungcheongnam-do, Korea;12. Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan;1. Department of Bioengineering and iBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal;2. Department of Medicine, Case Cardiovascular Research Institute, Harrington-McLaughlin Heart & Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA |
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| Abstract: | Background contextThe rs11190870 single nucleotide polymorphism in the 3'-flanking region of the LBX1 gene has been implicated in the etiology of adolescent idiopathic scoliosis (AIS). A thorough appraisal of the evidence supporting this association has not been previously attempted.PurposeTo provide a comprehensive assessment and synthesis of the currently available evidence on the association between rs11190870 and AIS.Study designA systematic review and meta-analysis.MethodsThis review followed the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. PubMed (MEDLINE), EMBASE, Scopus, and HuGE Literature Finder databases were systematically searched through November 2013 to identify relevant studies following a sensitive strategy. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using the fixed-effect inverse variance model for allelic (T vs. C) and genotypic comparisons.ResultsMeta-analysis of four studies conducted in East Asian populations (n=3,215 AIS cases and n=15,347 controls) found a highly statistically significant and robust association between rs11190870 and AIS. Comparison of summary ORs indicated a codominant model effect of the T allele. Carriers of the TC and TT genotypes were 69% (OR=1.69, 95% CI: 1.48–1.94, p<.001) and 162% (OR=2.62, 95% CI: 2.28–3.02, p<.001), respectively, more likely to have AIS compared with carriers of the CC genotype.ConclusionsBased on a comprehensive analysis of the currently available evidence, rs11190870 is likely a susceptibility variant for AIS in East Asians. Further investigation of this association is necessary in other populations. |
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| Keywords: | Adolescent idiopathic scoliosis Etiology Genetic association study LBX1 Ladybird homeobox 1 rs11190870 Single nucleotide polymorphism |
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