3.0T MRI 诊断和化疗后评估乳腺癌的可行性研究

目的探讨3.0T MRI在乳腺癌诊断和新辅助化疗后评估疗效方面的可行性。方法对72例乳腺癌病人进行乳腺MRI检查。而后,对其中30例在新辅助化疗4个疗程后进行MRI复查。MR扫描机为3.0T超高场装置。分析不同扫描序列的图像质量和病变表现。结果72例中,单发癌灶51例,多灶性癌灶19例,双侧乳腺均显示癌灶2例。癌灶直径范围是0.6-3.7cm。30例新辅助化疗后MRI复查：肿瘤完全消失2例,肿瘤缩小和TIC降级19例,肿瘤无变化6例,肿瘤进展3例。结论3.0T MRI在乳腺癌诊断和疗效评估方面可提供丰富的形态和功能信息。

Feasibility study of diagnosing and evaluating breast cancer after neoadjuvant chemotherapy at 3.0T MRI

Objective To explore the feasibility of diagnosing and evaluating breast cancers after neoadjuvant chemotherapy at 3.0T MRI. Methods Seventy-two patients with confirmed breast cancer performed MRI examinations at 3.0T scanner, then, 30 of them were followed up on MRI after neoadjuvant chemotherapy. Image quality, number and features of the lesions were analyzed on axial FSE T1WI, axial and sagittal STIR T2WI, axial SE-EPI DWI, and 3-dimentional dynamic contrast-enhanced MR imaging after intravenous gadolinium administration. Results Among seventy-two patients, single cancerous lesion in 51 cases, multifocal lesions in 19 cases, bilateral lesions in 2 cases were found. The diameter of the lesions ranged from 0.6-3.7 cm. Follow-up MRI after neoadjuvant chemotherapy showed that tumor size disappeared completely in 2 cases, became smaller in 19 cases, changed little in 6 cases, and progressed in 3 cases; other findings included weakening of enhanced signal intensities and degrading of time-signal intensity curves of the lesions on dynamic contrast-enhanced MR imaging. Conclusion 3.0T MRI was reliable, and capable of providing valuable architectural and functional information of breast cancers in the management of the patients.