锰对接触男工性腺激素水平的影响

目的：评价接触锰下丘脑一垂体一睾丸轴的影响，为保护工人生殖健康提供科学的参考依据。方法：应用放射免疫法测定了１８４名健康男工的血浆睾酮（Ｔ）、血清促间质细胞激素（ＬＨ）和促卵泡成熟激素（ＦＳＨ）含量，其中锰粉加工、冶炼、焊接和对照工人分别为３６，５０，２４和７４人。结果：冶炼作业环境空气中ＭｎＯ２浓度几何均值为０．１７ｍｇ／ｍ＾３，工人血清ＬＨ、ＦＳＨ含量高于对照组（ｐ〈０．０５～０．０１），而血

EFFECTS OF MANGANESE ON GONADAL HORMONE LEVEL IN MALE EXPOSED WORKERS

Objective:The aim of this study was to evaluate the effect of manganese exposure on the hypothalamo pituitary testicular axis for protecting workers' reproductive health Methods:The concentrations of plasma testosterone (T),serum luteinising hormone (LH) and follicle stimulating hormone (FSH) were determined in 36 silling workers,50 smelters,24 welders and 74 control workers by radioimmuno assay Results:The geometric mean of MnO 2 concentration in the air of the smelting worksites was 0 17 mg/m 3,concentrations of serum LH and FSH were both significantly higher in the exposed smelters,but plasma T was not significantly different between the exposed and control workers Compared with control workers,those exposed for 5~<10 years had significantly raised FSH and normal LH and T concentrations The multiple regression analysis showed that the negative correlation was found between the plasma T and air manganese concentrations,but no significant differences were found among the exposed and control groups Conclusion:There is an obvious secondary effect of manganese on the hypothalamo pituitary testicular axis