阿奇霉素治疗儿童支原体肺炎的临床疗效观察

目的:探讨阿奇霉素治疗儿童支原体肺炎的临床疗效和安全性。方法:80例肺炎支原体肺炎患儿随机分为观察组和对照组,每组各40例,观察组采用阿奇霉素治疗,对照组给予红霉素,2周后观察疗效。结果:观察组在体温恢复时间、咳嗽消失时间、肺部啰音消失时间和细菌转阴率方面,均好于对照组,二者比较,差异具有统计学意义(P<0.05);观察组总有效率为92.5%,对照组总有效率77.5%,二者比较具有显著性差异(P<0.05);观察组药物不良反应发生率为15.0%,对照组药物不良反应发生率为20.0%,二者比较无统计学意义(P>0.05)。结论:阿奇霉素治疗儿童支原体肺炎可以快速改善症状、治疗效果好、毒副反应小,值得临床推广应用。

Clinical observation on the therapeutic efficacy of azithromycin in treatment of children with mycoplasma pneumoniae pneumonia

OBJECTIVE To explore the therapeutic efficacy and safety of azithromycin in treatment of children with mycoplasma pneumoniae pneumonia.METHODS 80 cases of children with mycoplasma pneumoniae pneumonia were randomly divided into two groups with 40 cases each:the investigation group received the therapy of azithromycin,while the control group received the therapy of erythromycin,and then comparison was made between the two groups in clinical effects at the end of the course of 2 weeks’ treatment.RESULTS There were significant differences between the two groups about the time of body temperature recovering,cough dispearing,bellows rales dispearing and rate of bacterium dispearing after treatment(P<0.05);The total effective rate was 92.5% in the investigation group and 77.5% in control group respectively,it was significant difference between the both groups(P<0.05);The rate of adverse drug reactions was 15.0% in the investigation group,it was 20.0% in the control group,and there was no significant difference between the both groups(P>0.05).CONCLUSION The azithromycin in treatment of children with mycoplasma pneumoniae pneumonia has fastest onset,higher curative rate and lower side effect,and hence is worthy of being recommended in clinical practice.