| 地尔硫芯对葛根素药动学的影响 |
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| 引用本文： | 崔升淼,赵春顺. 地尔硫芯对葛根素药动学的影响[J]. 中国医院药学杂志, 2012, 0(10): 782-785 |
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| 作者姓名： | 崔升淼 赵春顺 |
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| 作者单位： | 广东药学院;中山大学 |
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| 摘 要： | 目的:研究地尔硫芯对葛根素血药浓度及药动学参数的影响。方法:应用高效液相色谱法测定与地尔硫芯合用前后葛根素的血药浓度。结果:注射合用后,地尔硫芯在低剂量时(0.5 mg·kg-1)对葛根素的药动学过程无显著性影响(P>0.05),但在高剂量时(2.5 mg·kg-1)有显著性影响(P<0.05)。结论:葛根素与地尔硫芯合用时,在一定浓度范围内,地尔硫芯可抑制葛根素从大鼠体内的消除;二者合并用药时应对葛根素进行临床给药监测。
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| 关 键 词： | 葛根素 地尔硫芯 药动学 |
Effect of diltiazem on the pharmacokinetics of puerarin in rats |
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| CUI Sheng-miao,ZHAO Chun-shun. Effect of diltiazem on the pharmacokinetics of puerarin in rats[J]. Chinese Journal of Hospital Pharmacy, 2012, 0(10): 782-785 |
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| Authors: | CUI Sheng-miao ZHAO Chun-shun |
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| Affiliation: | 1.Guangdong Pharmaceutical University,Guangdong Guangzhou 510006,China;2.Sun Yat-sen University,Guangdong Guangzhou 510006,China) |
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| Abstract: | OBJECTIVE To study the effect of diltiazem on serum concentration and pharmacokinetics of puerarin in rats.METHODS The concentration of puerarin in serum was detected by high performance liquid chromatography(HPLC) before and after diltiazem administration.RESULTS There was no significant difference was found between the control and 0.5 mg·kg-1 diltiazem combined groups for intravenous administration(P>0.05),and there was significant difference between the control and 2.5 mg·kg-1 diltiazem combined groups(P<0.05).CONCLUSION Diltiazem inhibited puerarin metabolism when puerarin was coadministered with diltiazem,so it is necessary to change the therapeutic dose of puerarin. |
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| Keywords: | puerarin diltiazem pharmacokinetics |
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